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肝细胞癌的免疫治疗

英文原题:Immunotherapy for hepatocellular carcinoma.

PubMed 2024/06/07(内容时间) Chin Med J (Engl) Q1 · IF 9.1(JCR 2025)

研究概要

其高复发率和缺乏有效控制药物导致5年生存率仅为约10%。

中文摘要

肝细胞癌(HCC)是全球癌症相关死亡的主要原因之一。其高复发率和缺乏有效控制药物导致5年生存率仅为约10%。HCC是一种受免疫系统调控的肿瘤。近年来,免疫治疗在实体瘤治疗中取得了重大突破。多种免疫疗法,如免疫检查点抑制剂(ICIs),包括联合治疗,在临床应用和研究中均显示出有前景的治疗效果。其他免疫疗法,如过继性细胞治疗和溶瘤病毒,也在不断涌现,为解决HCC的长期生存问题带来了希望。本文综述了当前常用的免疫治疗策略及最新研究进展,以供参考。

展开英文摘要原文

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide. Its high recurrence rate and lack of effective control drugs result in a 5-year survival rate of only about 10%. HCC is a tumor regulated by the immune system. Significant breakthroughs have occurred in treating solid tumors with immunotherapy in recent years. Various immunotherapies, such as immune checkpoint inhibitors (ICIs), including combination therapies, have demonstrated promising therapeutic effects in both clinical applications and research. Other immunotherapies, such as adoptive cell therapies and oncolytic viruses, are also emerging, offering hope for addressing long-term survival issues in HCC. This article reviews current commonly used immunotherapy strategies and the latest research findings for reference.

论文信息

作者
Wang X、Lu J
单位
Department of Medical Oncology, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China.China
文献类型
综述
期刊
Chinese medical journal2024 Aug 5
原文标识
PubMed 38855876 · DOI 10.1097/CM9.0000000000003060