肿瘤细胞治疗研究
英文原题：Glioblastoma stem cell metabolism and immunity.
尽管在脑恶性肿瘤新疗法的开发上投入了巨大的努力，但仍然迫切需要有效的治疗方法，尤其是对于儿童胶质母细胞瘤。
尽管在脑恶性肿瘤新疗法的开发上投入了巨大的努力，但仍然迫切需要有效的治疗方法，尤其是对于儿童胶质母细胞瘤。其预后不良被归因于传统疗法靶向肿瘤细胞，而非胶质母细胞瘤干细胞（GSCs）。GSCs的特征是自我更新、致瘤性、分化不良和耐药性。这些特征是重现肿瘤并导致复发所需的基本工具。本文讨论了GSCs改变代谢信号和逃避免疫细胞清除的机制，以及利用效应免疫细胞对抗GSCs的潜在策略。随着细胞免疫疗法在多种癌症中取得重大进展，利用这一尚未充分探索的潜力可能会显著改善脑恶性肿瘤的治疗选择。
Despite enormous efforts being invested in the development of novel therapies for brain malignancies, there remains a dire need for effective treatments, particularly for pediatric glioblastomas. Their poor prognosis has been attributed to the fact that conventional therapies target tumoral cells, but not glioblastoma stem cells (GSCs). GSCs are characterized by self-renewal, tumorigenicity, poor differentiation, and resistance to therapy. These characteristics represent the fundamental tools needed to recapitulate the tumor and result in a relapse. The mechanisms by which GSCs alter metabolic cues and escape elimination by immune cells are discussed in this article, along with potential strategies to harness effector immune cells against GSCs. As cellular immunotherapy is making significant advances in a variety of cancers, leveraging this underexplored reservoir may result in significant improvements in the treatment options for brain malignancies.
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