肿瘤细胞治疗研究
英文原题：Natural killer cell-mediated immune surveillance in cancer: Role of tumor microenvironment.
在针对癌症的免疫监视中，自然杀伤（NK）细胞是帮助清除变异细胞的关键效应细胞。
在针对癌症的免疫监视中，自然杀伤（NK）细胞是帮助清除变异细胞的重要效应细胞。本综述深入探讨了NK细胞与肿瘤微环境（TME）之间发生的复杂相互作用。本综述考察了细胞因子刺激如何影响NK细胞活化，重点关注TME内NK细胞功能的动态调节。它探讨了NK细胞相关生物标志物，如PD-1/PD-L1、甲基化HOXA9（Homeobox A9）、间质无反应性浸润前沿区域（SARIFA）和NKG2A/HLA-E，为预后和治疗结局提供了关键信息。免疫治疗不断变化的格局——包括检查点抑制剂、CAR-NK细胞和基于细胞因子的干预——在增强NK细胞活性的背景下得到了考察。本综述强调了未来精准医学的潜在路径，重点关注基于独特生物标志物谱的定制免疫治疗，并研究联合用药以产生更强抗肿瘤反应。
In the immunological surveillance against cancer, natural killer (NK) cells are essential effectors that help eradicate altered cells. The complex interactions that occur between NK cells and the tumor microenvironment (TME) are thoroughly examined in this review. The review examines how cytokine stimulation affects NK cell activation, focusing on the dynamic modulation of NK cell function within the TME. It looks at NK cell-related biomarkers such as PD-1/PD-L1, methylation HOXA9 (Homeobox A9), Stroma AReactive Invasion Front Areas (SARIFA), and NKG2A/HLA-E, providing critical information about prognosis and treatment outcomes. The changing landscape of immunotherapies-including checkpoint inhibitors, CAR-NK cells, and cytokine-based interventions-is examined in the context of enhancing NK cell activity. The review highlights the potential pathways for precision medicine going forward, focusing on customized immunotherapies based on unique biomarker profiles and investigating combination medicines to produce more robust anti-tumor responses.
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