肿瘤细胞治疗研究
英文原题：Breakthrough of solid tumor treatment: CAR-NK immunotherapy.
Breakthrough of solid tumor treatment: CAR-NK immunotherapy.
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作为最新且最受期待的肿瘤免疫治疗方法，CAR-NK 疗法近年来受到越来越多的关注，其安全性和高效性与 CAR-T 相比具有不可替代的优势。
作为最新且最受期待的肿瘤免疫治疗方法，CAR-NK 疗法近年来受到越来越多的关注，其安全性和高效性与 CAR-T 相比具有不可替代的优势。目前研究主要集中在 CAR-NK 在血液肿瘤中的应用，而在实体瘤中的研究较少。本文综述了 CAR-NK 的构建过程，缺氧和代谢因素、NK 细胞表面受体、细胞因子和外泌体对 CAR-NK 在实体瘤中疗效的影响，以及 CAR-NK 在多种实体瘤中的作用。CAR-NK 在临床实践中治疗实体瘤的作用机制和研究现状，并提出 CAR-NK 治疗实体瘤的优势、局限性和未来问题。
As the latest and most anticipated method of tumor immunotherapy, CAR-NK therapy has received increasing attention in recent years, and its safety and high efficiency have irreplaceable advantages over CAR-T. Current research focuses on the application of CAR-NK in hematological tumors, while there are fewer studies on solid tumor. This article reviews the process of constructing CAR-NK, the effects of hypoxia and metabolic factors, NK cell surface receptors, cytokines, and exosomes on the efficacy of CAR-NK in solid tumor, and the role of CAR-NK in various solid tumor. The mechanism of action and the research status of the potential of CAR-NK in the treatment of solid tumor in clinical practice, and put forward the advantages, limitations and future problems of CAR-NK in the treatment of solid tumor.
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