肿瘤细胞治疗研究
英文原题：Targeting Neutrophil Extracellular Traps: A Novel Antitumor Strategy.
Targeting Neutrophil Extracellular Traps: A Novel Antitumor Strategy.
手术、放疗和化疗对癌症的临床疗效通常受到肿瘤微环境（TME）恶化的限制。
手术治疗、放疗和化疗对癌症的临床疗效通常受到肿瘤微环境（TME）恶化的限制。中性粒细胞胞外诱捕网（NETs）是由中性粒细胞挤出的解聚染色质，广泛分布于胰腺癌、乳腺癌和肝细胞癌等多种癌症中。在TME中，NETs与基质成分、免疫细胞和癌细胞相互作用，从而重塑基质和细胞外环境，有利于癌症的发生、进展和转移。此外，NETs损害T细胞和NK细胞的增殖和活化，从而产生抑制性TME，限制免疫治疗的效果。更好地理解NETs在TME中的功能将为预防癌症转移和发现新的治疗策略提供新的机会。
The clinical efficacy of surgery, radiotherapy, and chemotherapy for cancer is usually limited by the deterioration of tumor microenvironment (TME). Neutrophil extracellular traps (NETs) are decondensed chromatin extruded by neutrophils and are widely distributed among various cancers, such as pancreatic cancer, breast cancer, and hepatocellular carcinoma. In the TME, NETs interact with stromal components, immune cells and cancer cells, which allows for the reshaping of the matrix and the extracellular environment that favors the initiation, progression, and metastasis of cancer. In addition, NETs impair the proliferation and activation of T cells and NK cells, thus producing a suppressive TME that restricts the effect of immunotherapy. A better understanding of the function of NETs in the TME will provide new opportunities for the prevention of cancer metastasis and the discovery of novel therapy strategies.
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