肿瘤细胞治疗研究
英文原题：Microphysiological model reveals the promise of memory-like natural killer cell immunotherapy for HIV(±) cancer.
这些结果表明，记忆样NK 细胞能够在没有T细胞辅助的情况下发挥作用，并且可以同时破坏头颈癌细胞以及减少病毒潜伏。
大量研究正在探索使用细胞过继疗法治疗血液系统恶性肿瘤以及实体瘤。然而，有许多因素会抑制免疫反应，包括人类免疫缺陷病毒等病毒。在本研究中，我们利用人源微生理模型对HIV-免疫系统相互作用进行逆向工程，并评估记忆样NK 细胞对HIV+头颈癌的潜力，头颈癌是人类免疫缺陷病毒感染者中最常见的肿瘤之一。在此，我们在人源生物工程环境中评估记忆样NK 细胞反应的多个方面，包括免疫细胞外渗、肿瘤穿透、肿瘤杀伤、T细胞依赖性、病毒抑制以及与逆转录病毒药物的相容性。总体而言，这些结果表明，记忆样NK 细胞能够在无T细胞辅助的情况下发挥作用，并可同时破坏头颈癌细胞以及减少病毒潜伏。
Numerous studies are exploring the use of cell adoptive therapies to treat hematological malignancies as well as solid tumors. However, there are numerous factors that dampen the immune response, including viruses like human immunodeficiency virus. In this study, we leverage human-derived microphysiological models to reverse-engineer the HIV-immune system interaction and evaluate the potential of memory-like natural killer cells for HIV + head and neck cancer, one of the most common tumors in patients living with human immunodeficiency virus. Here, we evaluate multiple aspects of the memory-like natural killer cell response in human-derived bioengineered environments, including immune cell extravasation, tumor penetration, tumor killing, T cell dependence, virus suppression, and compatibility with retroviral medication. Overall, these results suggest that memory-like natural killer cells are capable of operating without T cell assistance and could simultaneously destroy head and neck cancer cells as well as reduce viral latency.
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