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霍奇金淋巴瘤和 T 细胞淋巴瘤中的 CAR-T 细胞

英文原题:Chimeric Antigen Receptor T Cells in Hodgkin and T-Cell Lymphomas.

PubMed 2023/06/23(内容时间) Hematol Oncol Clin North Am Q2 · IF 3.1(JCR 2025)

研究概要

作者综述了嵌合抗原受体(CAR)转导T细胞(CAR-T)在霍奇金淋巴瘤(HL)和T细胞淋巴瘤(TCL)中的当前应用,并讨论了靶向CD30的CAR-T细胞的数据,这些细胞在HL中似乎安全且有效。

中文摘要

作者综述了嵌合抗原受体(CAR)转导T细胞(CAR-T)在霍奇金淋巴瘤(HL)和T细胞淋巴瘤(TCL)中的当前应用,并讨论了靶向CD30的CAR-T细胞的数据,这些细胞在HL中似乎安全有效。此外,作者探讨了靶向CD30、CD5或CD7的CAR-T细胞在TCL中的应用,同时强调了其在这一淋巴瘤亚型中使用的独特挑战。此外,作者提出了未来方向以及正在进行的探索CAR-T细胞在TCL和HL中应用的试验。

展开英文摘要原文

The authors review the current use of chimeric antigen receptor (CAR)-transduced T cells (CAR-T) in Hodgkin lymphoma (HL) and T-cell lymphomas (TCL) and discuss the data on CD30-targeting CAR-T cells, which seem to be safe and effective in HL. In addition, the authors examine the use of CAR-T cells targeting CD30, CD5, or CD7 in TCL, while highlighting the unique challenges of their use in this subset of lymphomas. Furthermore, the authors present future directions and ongoing trials investigating the use of CAR-T cells in TCL and HL.

论文信息

作者
Muhsen IN、Hill LC、Ramos CA
第一作者单位
Section of Hematology and Oncology, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and Houston Methodist Hospital, Houston, TX, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA.United States
通讯作者单位
Section of Hematology and Oncology, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and Houston Methodist Hospital, Houston, TX, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA. Electronic address: caramos@bcm.edu.United States
文献类型
综述 · 美国 NIH 资助研究 · 非美国政府资助研究
期刊
Hematology/oncology clinics of North America2023 Dec
原文标识
PubMed 37357070 · DOI 10.1016/j.hoc.2023.05.017