肿瘤细胞治疗研究
英文原题：Chimeric Antigen Receptor T-Cell Therapy for Solid Tumors.
我们综述了针对实体瘤的嵌合抗原受体（CAR）T细胞疗法。
我们综述了针对实体瘤的嵌合抗原受体（CAR）T细胞疗法。我们讨论了患者选择因素和临床管理方面。我们描述了挑战，包括CAR-T细胞运输的物理和分子障碍、免疫抑制性肿瘤微环境以及难以找到细胞表面靶抗原。描述了合成生物学和细胞工程在实体瘤CAR-T中的新方法应用。最后，我们总结了已报道和正在进行的针对特定疾病部位的CAR-T疗法临床试验，如头颈部（包括甲状腺癌）、肺、中枢神经系统（胶质母细胞瘤、神经母细胞瘤、胶质瘤）、肉瘤、泌尿生殖系统（前列腺、肾、膀胱、肾脏）、乳腺癌和卵巢癌。
We review chimeric antigen receptor (CAR) T-cell therapy for solid tumors. We discuss patient selection factors and aspects of clinical management. We describe challenges including physical and molecular barriers to trafficking CAR-Ts, an immunosuppressive tumor microenvironment, and difficulty finding cell surface target antigens. The application of new approaches in synthetic biology and cellular engineering toward solid tumor CAR-Ts is described. Finally, we summarize reported and ongoing clinical trials of CAR-T therapies for select disease sites such as head and neck (including thyroid cancer), lung, central nervous system (glioblastoma, neuroblastoma, glioma), sarcoma, genitourinary (prostate, renal, bladder, kidney), breast and ovarian cancer.
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