肿瘤细胞治疗研究
英文原题：Nanotechnology in cervical cancer immunotherapy: Therapeutic vaccines and adoptive cell therapy.
免疫治疗是一种新兴的宫颈癌治疗方法，比手术和放疗更有效，尤其是对复发性宫颈癌。
免疫治疗是宫颈癌治疗的一种新兴方法，比手术和放疗更有效，尤其是对复发性宫颈癌。然而，免疫治疗在临床实践中受到不良反应的限制。近年来，纳米技术已广泛用于肿瘤诊断、药物递送和靶向治疗。在宫颈癌中，纳米技术可用于主动或被动地将免疫治疗药物靶向肿瘤部位，从而增强局部药物递送、减少药物不良反应、实现免疫调节、改善肿瘤免疫微环境并优化治疗效果。在这篇综述中，我们重点介绍治疗性疫苗和过继细胞疗法在宫颈癌免疫治疗中的现状，以及脂质载体、聚合物纳米颗粒、无机纳米颗粒和外泌体在该背景下的应用。
Immunotherapy is an emerging method for the treatment of cervical cancer and is more effective than surgery and radiotherapy, especially for recurrent cervical cancer. However, immunotherapy is limited by adverse effects in clinical practice. In recent years, nanotechnology has been widely used for tumor diagnosis, drug delivery, and targeted therapy. In the setting of cervical cancer, nanotechnology can be used to actively or passively target immunotherapeutic agents to tumor sites, thereby enhancing local drug delivery, reducing drug adverse effects, achieving immunomodulation, improving the tumor immune microenvironment, and optimizing treatment efficacy. In this review, we highlight the current status of therapeutic vaccines and adoptive cell therapy in cervical cancer immunotherapy, as well as the application of lipid carriers, polymeric nanoparticles, inorganic nanoparticles, and exosomes in this context.
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