肿瘤细胞治疗研究
英文原题：Multiple Sclerosis and MEN2 Neoplasia in a Female Patient: A Unique Co-Existence with Expanded Immunological Interest and Therapeutical Challenges, before and after Patient's COVID-19 Infection.
Multiple Sclerosis and MEN2 Neoplasia in a Female Patient: A Unique Co-Existence with Expanded Immunological Interest and Therapeutical Challenges, before and after Patient's COVID-19 Infection.
多发性硬化（MS）及其可能观察到的各种共病引起了极大兴趣，因为MS病理生理学的复杂性以及随之而来的所有免疫学变化。
多发性硬化（MS）及其可能观察到的各种合并症，由于MS病理生理学的复杂性以及随之而来的所有免疫学变化，引起了极大的关注。MS中癌症的发病率已被研究多年，因为它不仅影响正在进行的治疗决策，而且某些疾病修饰治疗（DMTs）可能增加肿瘤发生的风险。我们首次报告了一例患有儿童期起病型MS（POMS）和多发性内分泌腺瘤病2B型（MEN2B）的女性患者病例，并在其COVID-19感染和SARS-CoV-2大流行的背景下，分析了这些疾病对治疗选择的免疫学影响。我们还回顾了关于这两种极为罕见疾病之间免疫遗传学和免疫学相关性的现有文献，并讨论了最适合本病例的治疗方案，由于当自然杀伤（NK）细胞中杀伤细胞免疫球蛋白样受体（KIR）表达降低时，抗CD20药物在推测的MS恶化和肿瘤进展方面具有更好的结局，因此该方案似乎是抗CD20药物。我们还扩展了对这一合并症问题的关注，同时聚焦于MS与癌症合并症这一尚未探索领域所需的未来研究。
Multiple sclerosis (MS) and its various comorbidities that may be observed are of great interest due to the complexity of MS pathophysiology and all of the immunological changes that follow. The incidence of cancer in MS has been investigated for several years, as not only does it affect ongoing therapeutical decisions, but also, certain disease-modifying treatments (DMTs) may increase the risk of tumorigenesis. For the first time, we present a case of a female patient with pediatric-onset MS (POMS) and multiple endocrine neoplasia 2B (MEN2B) and analyze the immunological impact of these diseases on the therapeutical choice, under the umbrella of her COVID-19 infection and the SARS-CoV-2 pandemic as a whole. We also review the existing literature regarding the immunogenetic and immunological correlations between these two extremely rare diseases and discuss the most suitable treatment for our case, which seems to be an anti-CD20 agent due to a better outcome in putative MS worsening and tumor progression, when killer immunoglobulin-like receptors' (KIR) expression is reduced in natural killer (NK) cells. We also broaden our concerns on this comorbidity issue, at the same time focusing on the future research needed in this unexplored field of the comorbidity of MS and cancers.
MEMBER ACCOUNT
登录成功会直接打开下一页。
