肿瘤细胞治疗研究
英文原题：Record Voxel Rate Nonlinear Optical Microscope to Unravel Brain Connectome and Signaling-Establish Reliably Electrophysiological Readouts From Human-induced Pluripotent Stem Cells (hiPSCs)-Derived Cerebral Organoids and Surgically Dissected Human Live Brains
⚠ 该试验的登记信息已有 26 个月未更新， 页面上显示的「招募中」可能已经失效。联系研究中心之前，建议先到 ClinicalTrials.gov 核对登记原文的最新状态与联系方式。
这是一项分期未标注的注册临床试验，评估细胞治疗用于脑肿瘤的安全性、可行性及初步疗效。当前状态：招募中。计划入组 500 例。试验地点：中国 · 台北（共 1 个中心，其中中国 1 个）。登记号：NCT05921786。
不限性别 · ≥ 18 Years
入选标准： 1. 年龄>18岁，确诊脑部疾病（新诊断或复发），适合并愿意接受切除手术。 排除标准： 1. 无法提供参加研究的知情同意。 2. 肿瘤样本经标准病理流程仍无法获得明确病理诊断。 3. 仅接受活检而非切除手术。 4. 病理检查提示明显放疗后改变或放射性坏死。
Inclusion Criteria: 1\. Patients older than the age of 18 with diagnosis of brain disease (both newly-diagnosed or recurrent) who are suitable and willing to receive resection surgery. Exclusion Criteria: 1. Patients who cannot give consent to participate in the study. 2. The tumor samples failed to give a conclusive pathological diagnosis by standard pathological workflow. 3. Patients who only receives biopsy surgery rather than resection surgery. 4. Significant post-irradiation effect or radiation necrosis reported in the pathological examination.
以上为辅助阅读译文。是否适合入组须由主治医生判断，最终以登记平台与研究者确认为准。
主要终点：Acquire neuronal structual (image frame) results of different brain regions · By interpreting the microscopic images of different brain regions' tissues , an attempt is made to understand the structure of brain disease tissues (via cell morphology, microvessels, etc). · 3 years；Acquire electrophysiological readout (voltage amplitude, mV) datas of different brain regions · By interpreting the neuron electric reactive datas, an attempt is made to know the neuronal activity (via detecting voltage amplitude change) between multiple neurons. · 3 years
次要终点：To conduct imaging for multiple types of human brain tissues and construct the neuron image database
本研究旨在建立多种脑组织的大型数据库，并验证人脑组织模型及 hiPSC 来源类器官模型的相关性。
The research aims to establish a big database of multiple kinds of brain tissues and prove the relevance of human brain tissue models and hiPSCs-derived organoid models.
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