溶瘤寨卡病毒疗法利用 CCR2+ 单核细胞增强抗胶质母细胞瘤的 T 细胞应答
Oncolytic zika virus therapy leverages CCR2+ monocytes to boost anti-glioblastoma T cell responses.
ZIKV 驱动的 CCR2+单核细胞活化和募集通过增强细胞毒性和限制耗竭,支持强效的抗肿瘤 CD8+ T 细胞应答。这些发现凸显了调节单核细胞-T 细胞交互作用以克服 GBM 中免疫抑制此前未被认识的治疗潜力。
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现在就能报名的(招募中)排在最前,共 1 项。同一状态内中国中心优先。信息来自 ClinicalTrials.gov 与 CDE 公开登记。能否入组、费用与可及性,以登记原文和主治医生判断为准。
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Oncolytic zika virus therapy leverages CCR2+ monocytes to boost anti-glioblastoma T cell responses.
ZIKV 驱动的 CCR2+单核细胞活化和募集通过增强细胞毒性和限制耗竭,支持强效的抗肿瘤 CD8+ T 细胞应答。这些发现凸显了调节单核细胞-T 细胞交互作用以克服 GBM 中免疫抑制此前未被认识的治疗潜力。
Next-generation therapeutics for glioblastoma: Challenges and future directions.
Developing a multimodal therapy for glioblastoma using oncolytic virus delivering CD19 and EGFRvIII antigens and bi-specific CARs.
Diffuse intrinsic pontine glioma in the era of H3 K27-altered diffuse midline glioma.
Metabolic dependencies and neural progenitor dysregulation: driving forces in paediatric high-grade glioma development.
Immunosuppressive Tumor Microenvironment and Therapeutic Landscape of Diffuse Intrinsic Pontine Glioma.
Immunotherapy for Glioma: A compartmental framework for resistance and rational combination design.
Persistent T cell activation and cytotoxicity against glioblastoma following single oncolytic virus treatment in a clinical trial.
Advancing chimeric antigen receptor T-cell therapy frontiers in glioblastoma: Navigating the current landscape from clinical hurdles to breakthrough s
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