CELL INTELLIGENCE · 肿瘤细胞治疗研究

用于靶向实体瘤的嵌合抗原受体的二硫键导向多环肽

Disulfide-Directed Multicyclic Peptides for Chimeric Antigen Receptors Targeting Solid Tumors.

CAR-T 细胞递送 CD47 阻断剂 SIRPα-Fc 增强抗肿瘤疗效

Delivery of CD47 blocker SIRPα-Fc by CAR-T cells enhances antitumor efficacy.

靶向 Glypican 3 的 CAR-T 细胞分泌靶向 TROP2 的双特异性 T 细胞衔接器对肺鳞状细胞癌表现出强效疗效

Glypican 3-targeted chimeric antigen receptor T cells secreting TROP2-directed bispecific T cell engagers exhibit potent efficacy against lung squamou

本研究表明，GPC3 CAR-T。

TROP2 靶向 CAR-T 细胞疗法的系统性工程化改造克服实体瘤耐药通路

Systematic Engineering of TROP2-Targeted CAR T-Cell Therapy Overcomes Resistance Pathways in Solid Tumors.

双抑制域 iCAR 提升 AND-NOT 门控 CAR-T 策略的效率

Dual-inhibitory domain iCARs improve the efficiency of the AND-NOT gate CAR T strategy.

由肽和蛋白免疫原产生的抗 Trop2 胞外域抗体靶向 Trop2 阳性肿瘤细胞的比较

Comparison of Anti-Trop2 Extracellular Domain Antibodies Generated Against Peptide and Protein Immunogens for Targeting Trop2-Positive Tumour Cells.