下一代基于抗体的癌症治疗:抗体-药物偶联物和双特异性抗体在血液系统恶性肿瘤和实体瘤中的应用
Next-generation antibody-based therapeutics in cancer: antibody-drug conjugates bispecific antibodies across hematologic malignancies and solid tumors
肿瘤学的治疗范式正在经历由抗体药物偶联物(ADC)和双特异性抗体(bsAb)驱动的深刻变革。
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Next-generation antibody-based therapeutics in cancer: antibody-drug conjugates bispecific antibodies across hematologic malignancies and solid tumors
肿瘤学的治疗范式正在经历由抗体药物偶联物(ADC)和双特异性抗体(bsAb)驱动的深刻变革。
Expansion and CAR engineering of granulocyte-monocyte progenitors for cellular immunotherapy.
这些发现确立了可扩增GMP作为工程化免疫治疗的可扩展平台。
Advances in CAR-T therapy for central nervous system tumors.
CAR-T 细胞疗法在中枢神经系统肿瘤中的应用已取得显著进展;
Prognostic and Predictive Value of Immune-Related Gene Expression Signatures vs Tumor-Infiltrating Lymphocytes in Early-Stage ERBB2/HER2-Positive Brea
本研究结果表明,多个B细胞相关特征与pCR和EFS的关联比主要代表T细胞的TILs更强。当同时具备TILs和基因表达数据时,免疫相关特征的预后价值似乎更优。
Immunogenetic Metabolomics Reveals Key Enzymes That Modulate CAR T-cell Metabolism and Function.
这些数据共同揭示了对 CAR T 细胞代谢重编程的系统性认识,并揭示了改进 CAR T 细胞疗法的潜在靶点。
An Inhibitory Role for Human CD96 Endodomain in T Cell Anti-Tumor Responses.
我们的发现共同提示 CD96 胞内结构域在减弱 T 细胞细胞毒性中发挥作用,并支持靶向多个而非单一免疫检查点的联合肿瘤免疫治疗。
A CD19-Anti-ErbB2 scFv Engager Protein Enables CD19-Specific CAR T Cells to Eradicate ErbB2(+) Solid Cancer.
CD19特异性CAR T细胞治疗白血病/淋巴瘤的疗效,至少部分依赖于特定CAR的独特性质以及健康B细胞的存在,后者通过反复刺激增强靶细胞裂解和细胞因子分泌。
Expression of TRX1 optimizes the antitumor functions of human CAR T cells and confers resistance to a pro-oxidative tumor microenvironment.
使用嵌合抗原受体(CAR)T 细胞治疗 B 细胞淋巴瘤和白血病已取得显著成功。
Cardiac Toxicity Associated with Cancer Immunotherapy and Biological Drugs.
肿瘤免疫治疗对改善肿瘤患者的预后有显著贡献。
A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy.
嵌合抗原受体(CAR)T细胞疗法已成为一种开创性的癌症治疗方法,在治疗某些血液系统恶性肿瘤如淋巴瘤和白血病方面取得了前所未有的成功。
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