FECH:影响 CAR-T 细胞表型与功能的新型代谢靶点
FECH, a novel metabolic target influencing CAR T-cell phenotype and function.
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FECH, a novel metabolic target influencing CAR T-cell phenotype and function.
Novel CAR T cell blend targeting PDPN and GD2 to overcome glioblastoma heterogeneity.
这种新型 PDPN/GD2 CAR-T 细胞混合物在晚期临床前胶质母细胞瘤模型中显示出强效疗效,提示其具有治疗异质性胶质母细胞瘤和解决单抗原 CAR-T 细胞疗法相关局限性的潜力。
Dual targeting of PDPN and GD2 enhances CAR T cell efficacy against glioblastoma and promotes durable tumor control.
GD2-targeted immunotherapy in pediatric bone sarcomas: a systematic review of emerging strategies and combination approaches.
GD2 在小儿骨肉瘤中是一个具有生物学相关性和临床前景的靶点。然而,重大的转化挑战仍然存在,包括有限的临床数据、异质性的研究设计,以及缺乏用于 GD2 表达评估的标准化检测方法。需要进一步的国际合作研究,以优化患者选择并加速 GD2 靶向联合免疫治疗策略的开发。
De novo H3.3K27M-altered diffuse midline glioma in human brainstem organoids to dissect GD2 CAR T cell function.
CAR T cells targeting the glycoprotein GD2 show potent antitumor efficacy in high-risk ependymoma models.
Publisher Correction: GD2-targeting CAR T cells in high-risk neuroblastoma: a phase 1/2 trial.
Metabolic and Post-Translational Vulnerabilities of Glioblastoma: Disulfidptosis, Glycosylation, and Implications for CAR-T Therapy.
GD2-targeting CAR T cells in high-risk neuroblastoma: a phase 1/2 trial.
Targeting GD2 with CAR-T Cell Therapy in Neuroblastoma: Updates, Challenges, and Future Perspectives.
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