肿瘤细胞治疗研究
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Engineering Interferon-γ-Enhanced Chimeric Antigen Receptor Macrophages via Lipid-Assisted Polymeric Nanoparticles for Cancer Immunotherapy.
目的 To develop an efficient strategy for in vivo engineering of M1-like CAR-Ms for cancer therapy. 方法 We designed a lentiviral vector encoding a CAR targeting BCMA and a cytokine cassette. Macrophages were transduced and
Acidity-targeting transition-aided universal chimeric antigen receptor T-cell (ATT-CAR-T) therapy for the treatment of solid tumors.
CAR-T 细胞用于治疗实体瘤时经常面临重大挑战，主要原因是肿瘤抗原的异质性。
Programmable Attenuation of Antigenic Sensitivity for a Nanobody-Based EGFR Chimeric Antigen Receptor Through Hinge Domain Truncation.
这些结果表明，铰链长度调节提供了一种可编程策略，用于调节靶向膜近端表位的 CARs 的抗原敏感性，并可用于 CAR 优化和提高肿瘤选择性。
Visualizing Spatial and Stoichiometric Barriers to Bispecific T-Cell Engager Efficacy.
我们的研究确定了 BiTE 分子在实体瘤中发挥最佳疗效的多项必要条件，为实体癌免疫治疗开发提供了可资利用的见解。
CXCR3 enhanced murine chimeric antigen receptor T cells in the treatment of solid tumors.
CXCR3过表达通过增强肿瘤浸润增强了CAR-T在实体瘤中的抗肿瘤能力。该策略为克服CAR-T治疗当前的局限性提供了一种有前景的方法。
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