FNDC4 驱动胰腺癌的转移和免疫逃逸
FNDC4 Drives Metastasis and Immune Evasion in Pancreatic Cancer.
靶向FNDC4的效果导致在免疫健全的小鼠PDAC模型中肿瘤负荷减少、转移受到抑制,并提高了生存率。
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FNDC4 Drives Metastasis and Immune Evasion in Pancreatic Cancer.
靶向FNDC4的效果导致在免疫健全的小鼠PDAC模型中肿瘤负荷减少、转移受到抑制,并提高了生存率。
Emerging claudin-18.2 antagonists in the treatment of biliary tract cancer.
靶向 CLDN-18.2 是治疗实体瘤(包括 BTC)的一种有前景的新方法。
Claudin18.2 as a Promising Therapeutic Target in Gastric Cancer.
Claudin-18.2(CLDN18.2)是紧密连接蛋白的一种亚型,已成为胃癌(GC)中有前景的治疗靶点。
Zolbetuximab as a gastric lineage-directed immunotherapy: mechanistic rationale and translational evidence in CLDN18.2-positive gastroesophageal adeno
Zolbetuximab代表了一种新型治疗类别,可归类为靶向溶细胞抗体。未来的工作应测试与检查点阻断的联合治疗,完善生物标志物,并明确耐药机制。
Brave new world-new and emerging treatments for gastric cancer.
对于约 20% 存在人表皮生长因子受体 2(HER2)过表达的胃癌(GC),近期已确立了以曲妥珠单抗形式加用 HER2 阳性靶向治疗的作用。
Emerging targets in gastroesophageal adenocarcinoma: what the future looks like.
胃食管腺癌(GEA)是一种异质性疾病,预后差。
Anti-Claudin Treatments in Gastroesophageal Adenocarcinoma: Mainstream and Upcoming Strategies.
Claudin 18.2(CLDN18.2)被认为是治疗晚期胃食管腺癌(GEAC)的一个有前景的靶点,在近 30% 的转移性病例中呈高表达。
Innovative CAR-T approaches targeting Claudin 18.2 to counteract drug resistance in gastric cancer.
Claudins是紧密连接的整合组分,近年来已成为胃癌耐药性的关键调节因子。
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