下一代基于抗体的癌症治疗:抗体-药物偶联物和双特异性抗体在血液系统恶性肿瘤和实体瘤中的应用
Next-generation antibody-based therapeutics in cancer: antibody-drug conjugates bispecific antibodies across hematologic malignancies and solid tumors
肿瘤学的治疗范式正在经历由抗体药物偶联物(ADC)和双特异性抗体(bsAb)驱动的深刻变革。
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Next-generation antibody-based therapeutics in cancer: antibody-drug conjugates bispecific antibodies across hematologic malignancies and solid tumors
肿瘤学的治疗范式正在经历由抗体药物偶联物(ADC)和双特异性抗体(bsAb)驱动的深刻变革。
Safety and Clinical Outcomes of a First-in-Human Trial of Point-of-Care Manufactured Trispecific CAR T Cells Targeting CD19, CD20, and CD22.
总体缓解率为50%,其中淋巴瘤患者的完全缓解率为83%。
Mosunetuzumab plus polatuzumab vedotin for relapsed/refractory MCL after BTK inhibitor therapy: a phase 2 study.
共纳入42例患者,既往治疗中位数为3线;26%既往接受过CAR T细胞治疗。
Rituximab Binding Endows CD20+ Extracellular Vesicles With NK Cell-Activating Properties in B Cell Lymphoma.
这些结果表明,抗体结合可赋予 EV 新的免疫调节特性,揭示了治疗性抗体重塑 EV 功能并影响抗肿瘤免疫的潜在机制。
Short ramp-up glofitamab halves mortality risk after anti-CD19 CAR T-cell therapy failure in patients with diffuse large B-cell lymphoma: final result
在这项稳健的疗效比较研究中,CAR-T 细胞治疗失败后首次复发或进展时给予短爬坡 glofitamab,与同期非双特异性挽救治疗相比显著提高了生存机会。
Durable efficacy and manageable long-term safety of lisocabtagene maraleucel in 3L+ FL: 3-year update from TRANSCEND FL.
在此,我们报告了三线或更后线(3L+)FL患者的3年随访结果(中位[范围]在研随访时间为41.5个月[0.3-54.0])。
Clinical outcomes and spatial transcriptomic profiles of CD19/20 CAR-T therapy in relapsed or refractory B-cell non-Hodgkin's lymphoma.
双特异性 CD19/20 CAR-T 疗法产生了持久的临床活性,且毒性可控。
Demethylation-primed tandem CD19/CD20 CAR T cells in relapsed/refractory B-cell lymphoma: a phase I/II trial.
在此,我们报告一项开放标签非随机I/II期试验(NCT04697940),评估经DAC预处理的CD19/CD20双靶向CAR T细胞(dCAR T)在23例复发或难治性NHL患者中的应用。
Peripheral CD8⁺ T-cell clonality and NK-cell expansion mark early response to mosunetuzumab in indolent B-cell lymphoma.
这些发现定义了mosunetuzumab治疗下的一种CD8+效应重塑状态,其特征为克隆扩增、选择性抑制性受体表达、胆固醇生物合成的持续激活以及与细胞因子相关的先天免疫机制参与,为支持T细胞功能和增强双特异性抗体疗效的潜在策略提供了框架。
Development of tandem canine CAR T cells to enable comparative studies of aggressive B-cell lymphoma.
抗CD19CAR-T(CAR T)细胞对弥漫大B细胞淋巴瘤(DLBCL)具有令人期待的治疗潜力,但许多接受治疗的患者因CD19阴性克隆驱动的疾病进展而复发。
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