CELL INTELLIGENCE · 肿瘤细胞治疗研究

双顺反子抗 CD19/CD20 CAR 构建体的开发，包括消除非预期核酸序列缺失

Development of a bicistronic anti-CD19/CD20 CAR construct including abrogation of unexpected nucleic acid sequence deletions.

为解决抗 CD19 嵌合抗原受体（CAR）T 细胞治疗后淋巴瘤 CD19 丢失的问题，我们设计了一种编码抗 CD19 CAR 和抗 CD20 CAR 的双顺反子构建体。