下一代基于抗体的癌症治疗:抗体-药物偶联物和双特异性抗体在血液系统恶性肿瘤和实体瘤中的应用
Next-generation antibody-based therapeutics in cancer: antibody-drug conjugates bispecific antibodies across hematologic malignancies and solid tumors
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Next-generation antibody-based therapeutics in cancer: antibody-drug conjugates bispecific antibodies across hematologic malignancies and solid tumors
Bispecific antibodies and dual-targeting CAR-T cells for multiple myeloma: latest updates from the 2023 ASCO annual meeting.
Unveiling causal immune cell-gene associations in multiple myeloma: insights from systematic reviews and Mendelian randomization analyses.
我们的研究支持 CAR-T 细胞疗法在 rrMM 患者中的疗效和安全性,ORR 为 82.2%,严重 CRS(6.3%)和神经毒性(0.9%)发生率低。这一发现还提示 BCMA/CD19 双特异性 CAR-T 细胞具有更优的 ORR,尚待临床确认。MR 分析揭示了免疫细胞、VDR 和 VHL 等基因与 MM 之间的关联,增进了我们对其病理生理学的理解。
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