CAR-T 细胞疗法在实体瘤中的挑战与局限:为何获批仅限于血液系统恶性肿瘤?
Challenges and limitations of chimeric antigen receptor T-cell therapies in solid tumors: why are approvals restricted to hematologic malignancies?
CAR-T 细胞治疗彻底改变了血液系统恶性肿瘤的治疗,提供了一种高度个体化且强效的免疫治疗手段。
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Challenges and limitations of chimeric antigen receptor T-cell therapies in solid tumors: why are approvals restricted to hematologic malignancies?
CAR-T 细胞治疗彻底改变了血液系统恶性肿瘤的治疗,提供了一种高度个体化且强效的免疫治疗手段。
Tumor-priming CD8(+) natural killer T-like cells as an efficient novel cell therapy for relapsed/refractory multiple myeloma.
TPNC 是一种通过肿瘤驱动的致敏产生的新型细胞毒性淋巴细胞产品。
Signal Detection and Machine Learning-Based Prediction of Cytokine Release Syndrome in B-Cell Maturation Antigen-Targeting Immunotherapies Using FAERS
结果:在最终数据集纳入的 4046 份报告中,CAR-T 疗法显示出比 BsAbs 更高的 CRS 报告比值比(aOR:2.55,95% CI:2.16-3.01)。
Infectious complications after CAR T-cell therapy: mechanisms, risk stratification, and prevention.
嵌合抗原受体(CAR)T 细胞疗法是复发或难治性 B 细胞恶性肿瘤的成熟治疗手段。
BCMA biology and therapeutic targeting in multiple myeloma: From ligand signaling to antigen escape.
B 细胞成熟抗原(BCMA;TNFRSF17)已迅速从 BAFF/APRIL 网络中的浆细胞存活受体演变为多发性骨髓瘤(MM)的核心治疗枢纽。
CAR-Based Cell and Gene Therapies: Global Clinical Landscape and Emerging Therapeutic Strategies from ClinicalTrials.gov.
约 92% 的试验针对肿瘤,其中血液系统恶性肿瘤占 65% 的适应症;CD19 和 BCMA 是 III 期研究中的主要靶点。
Incidence of immune effector cell-associated neurotoxicity among patients treated with CAR T-cell therapy for hematologic malignancies: systematic rev
CAR T 细胞疗法相关 ICANS 的总体发生率为全级别 26.9%、高级别 10.5%。
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