决定异体 CAR T 细胞排斥与扩增的细胞和分子机制
Cellular and molecular mechanisms determining allogeneic CAR T cell rejection and expansion.
我们评估了11例接受单一批次cemacabtagene ansegedleucel(cema-cel)治疗的大B细胞淋巴瘤患者,cemacabtagene ansegedleucel是一种异体抗CD19 CAR T产品。
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Cellular and molecular mechanisms determining allogeneic CAR T cell rejection and expansion.
我们评估了11例接受单一批次cemacabtagene ansegedleucel(cema-cel)治疗的大B细胞淋巴瘤患者,cemacabtagene ansegedleucel是一种异体抗CD19 CAR T产品。
RHOA Deletion Downregulates CD19 and Promotes Dysfunctional Immune Microenvironments in CAR-T Resistant Large B-cell Lymphomas.
CD19靶向嵌合抗原受体(CAR)-T细胞是大B细胞淋巴瘤的突破性疗法,但不到一半的患者能获得持久缓解。
Five-year survival outcomes of lisocabtagene maraleucel in R/R LBCL from the TRANSCEND NHL 001 study.
这些数据支持liso-cel在R/R LBCL患者中的治愈潜力。
Safety and Clinical Outcomes of a First-in-Human Trial of Point-of-Care Manufactured Trispecific CAR T Cells Targeting CD19, CD20, and CD22.
总体缓解率为50%,其中淋巴瘤患者的完全缓解率为83%。
A Patient-Derived Xenograft Repository Capturing Clinical and Molecular Heterogeneity of Large B-cell Lymphoma.
未标注:大B细胞淋巴瘤(LBCL)是一组在临床和分子层面具有高度异质性的恶性肿瘤,其治疗格局正在迅速演变,由此带来了新的临床需求领域,例如CD19CAR-T 细胞(CART19)治疗后进展。
Publisher Correction: Decade-long persistence of CD19 CAR T cells in B cell lymphomas.
B-Cell Lymphomas, Version 4.2026, NCCN Clinical Practice Guidelines In Oncology.
套细胞淋巴瘤(MCL)是B细胞非霍奇金淋巴瘤(NHL)的一种异质性亚型。
Tumor CD19 Expression Determines Distinct Clinical Outcomes After CD19 CAR T-Cell Therapy in Large B-Cell Lymphoma.
我们在一个 LBCL 队列(n=301)中,通过流式细胞术(FC)、免疫组化和 RNA 测序进行集中定量评估,对肿瘤 CD19 水平开展了整合分析。
T-cell immunosenescence limits CD19 CAR T-cell function in chronic lymphocytic leukemia.
这些数据共同表明,免疫衰老是 CLL 中 CAR-T 细胞疗效的一个可测量且具有功能后果的障碍,也是治疗调节的候选靶点。
BAFF-R CAR T-cell therapy for relapsed or refractory B-cell lymphomas.
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