曲妥珠单抗耐药,乳腺癌最成功治疗的潜在障碍——对潜在机制、临床试验和规避耐药专利的最新综述
Trastuzumab Resistance, a Potential Roadblock for Most Successful Therapy of Breast Cancer-An Updated Review of Underlying Mechanisms, Clinical Trials
曲妥珠单抗是首个用于乳腺癌(BC)治疗的人源化单克隆抗体(Mab)。
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Trastuzumab Resistance, a Potential Roadblock for Most Successful Therapy of Breast Cancer-An Updated Review of Underlying Mechanisms, Clinical Trials
曲妥珠单抗是首个用于乳腺癌(BC)治疗的人源化单克隆抗体(Mab)。
Molecular alterations of muc1 and their therapeutic exploitation: Emerging opportunities in cancer therapy.
Mucin 1 (MUC1) 是一种跨膜糖蛋白 (TGP),通常表达于上皮表面,在多种恶性肿瘤中异常过表达且低糖基化 (HG),包括肺癌、乳腺癌、胰腺癌、卵巢癌和血液系统恶性肿瘤。
iPSC-derived polyvalent vaccines as ontogenetically informed immunogens toward overcoming immune refractoriness in microsatellite-stable colorectal ca
转化优先级包括 CRISPR 工程化的低免疫原性 iPSC 平台、符合 GMP 的非整合重编程,以及与 STING 激动剂、ICB、CAR-NK 细胞和 LNP-mRNA 构建体的组合整合,以在微小残留病灶 CRC 中实现生物标志物引导的临床部署。
Emerging Landscape of CAR-T Cell Therapy in Colon Cancer: Mechanistic Insights, Clinical Advances, Challenges, and Future Directions.
CAR-T 细胞疗法已经彻底改变了血液系统恶性肿瘤的治疗;然而,其向实体瘤(包括结肠癌)的临床转化仍然面临挑战。
Chimeric antigen receptor T-cell therapy for solid tumors: A review of the intricate mechanisms and potential strategies.
CAR-T 细胞疗法已经彻底改变了癌症免疫治疗,在血液系统恶性肿瘤中取得了显著成功。
MUC1-targeted CAR-T cell secreted anti-PD-1 IgG antibody enhances antitumor activity in Cholangiocarcinoma.
这些发现表明,在CCA背景下,全长抗PD-1免疫球蛋白的分泌增强了CAR-T细胞功能和抗肿瘤活性。
CAR-T cell therapy in breast cancer management: expanding horizon and overcoming challenges beyond hematologic cancers.
乳腺癌(BC)仍然是发病率最高、治疗最具挑战性的癌症之一,目前的治疗方法往往受到治疗耐药和不良反应的限制。
An In Vitro Comparison of Costimulatory Domains in Chimeric Antigen Receptor T Cell for Breast Cancer Treatment.
我们的研究结果表明,靶向MUC1的CAR T细胞可有效对抗MUC1+乳腺癌细胞,并支持在乳腺癌治疗的临床前和临床研究中进一步开发含有41BB信号的CAR MUC1 T细胞。
Cytotoxic activity of anti-mucin 1 chimeric antigen receptor T cells expressing PD-1-CD28 switch receptor against cholangiocarcinoma cells.
M.CAR/SR T细胞的细胞毒性功能较M.CAR T细胞增强,有望进一步用于CCA治疗的测试。
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