靶向 CD79b 的三种新型 CAR 用于非霍奇金淋巴瘤治疗的临床前开发及靶抗原丢失特征分析
Preclinical development of three novel CARs targeting CD79b for the treatment of non-Hodgkin's lymphoma and characterization of the loss of the target
基于特异性、疗效和靶抗原丢失,CARLY3 代表了一种针对非霍奇金淋巴瘤的潜在新型 CAR 治疗。
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Preclinical development of three novel CARs targeting CD79b for the treatment of non-Hodgkin's lymphoma and characterization of the loss of the target
基于特异性、疗效和靶抗原丢失,CARLY3 代表了一种针对非霍奇金淋巴瘤的潜在新型 CAR 治疗。
CAR T cells with dual targeting of CD19 and CD22 in pediatric and young adult patients with relapsed or refractory B cell acute lymphoblastic leukemia
我们开展了一项针对复发或难治性B-ALL儿童及年轻成人患者(n = 15)的1期试验,以测试AUTO3——表达抗CD19和抗CD22 CAR的自体转导T细胞(AMELIA试验,EUDRA CT 2016-004680-39)。
Outcome of chimeric antigen receptor T-cell therapy following treatment with inotuzumab ozogamicin in children with relapsed or refractory acute lymph
在这项国际性回顾性分析中,分析了39名儿童和年轻成人,他们在T细胞采集前(n = 12)和/或后(n = 27)接受InO作为CART-19治疗的桥接治疗。
Inotuzumab ozogamicin as single agent in pediatric patients with relapsed and refractory acute lymphoblastic leukemia: results from a phase II trial.
年龄 1-18 岁、R/R CD22⁺ BCP-ALL 患者按 RP2D 1.8 mg/m² 接受治疗。
CAR-T Cell Therapy in B-Cell Acute Lymphoblastic Leukemia.
CD19 CAR-T细胞在儿童和成人R/R B-ALL患者中均诱导高比例(80-90%)的完全缓解。
CAR-T Cell Therapy in the Treatment of Pediatric Non-Hodgkin Lymphoma.
这种癌症可发生于任何年龄的儿童,但在 5 岁以下相当罕见。
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