肿瘤细胞治疗研究
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Locoregional infusion of EGFR806-CAR T cells for recurrent or refractory pediatric CNS tumors: Results of the completed BrainChild02 phase 1 clinical
颅内输注EGFR806-CAR T细胞在测试剂量下可耐受，最佳反应为疾病稳定。EGFR是针对儿童脑肿瘤，特别是高级别胶质瘤的细胞治疗的潜在有用靶点。
Precision targeting of rhabdomyosarcoma by combining primary CAR NK cells and radiotherapy.
本研究为 EGFR-CAR NK 细胞作为 RMS 的一种有前景的免疫疗法提供了概念验证，尤其是与放疗联合使用时，可克服实体瘤的障碍。
Locoregional and systemic adoptive cellular therapies for pediatric brain tumors: a systematic review of CAR‑T, TCR‑engineered T cells, and NK cell st
检索获得324条记录；去除103条重复记录；筛选221篇标题和摘要；审阅180篇全文；由两名独立评价者提取34项研究。
CAR T Cell Therapy in Primary Brain Tumors: Current Investigations and the Future.
CAR-T 细胞（CAR T细胞）是经过工程化改造的细胞，表达针对特定肿瘤抗原（TA）的嵌合抗原受体（CAR），从而能够识别并清除癌细胞。
Full-length recombinant antibodies from Escherichia coli: production, characterization, effector function (Fc) engineering, and clinical evaluation.
尽管在大肠杆菌中生产的几种抗体片段和抗体片段融合蛋白已被证明是安全有效的治疗药物，但产量低和易形成包涵体仍然是限制其广泛应用的主要障碍。
Identification of molecularly targeted therapy-induced immunopeptidome in diffuse midline glioma (DMG).
MTX-241F 改变了胶质瘤免疫肽组，揭示 H2B1K、脑富集免疫肽以及治疗诱导的免疫肽是免疫可见的靶点。
Latest Advancements in the Management of H3K27M-Mutant Diffuse Intrinsic Pontine Glioma: A Narrative Review.
尽管近年来在弥漫性内生性桥脑胶质瘤（DIPG）的放疗方面取得了进展，但该病的预后仍然很差，凸显出需要新的治疗策略来改善结局。
Pediatric Hemispheric High-Grade Gliomas and H3.3-G34 Mutation: A Review of the Literature on Biological Features and New Therapeutic Strategies.
近50%的pHGG存在编码组蛋白3的基因突变，包括携带H3.3-G34突变的亚型。
Review: therapeutic approaches for circadian modulation of the glioma microenvironment.
高级别胶质瘤是恶性脑肿瘤，因其特性而难以治疗；它们在成人中生长迅速，并侵袭性地穿过脑组织，且对放化疗产生耐药性。
Chimeric Antigen Receptor T cell Therapy and the Immunosuppressive Tumor Microenvironment in Pediatric Sarcoma.
肉瘤是一组多样化的骨和软组织肿瘤，占儿童癌症的10%以上。
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