可扩展生成靶向实体瘤的造血干细胞工程化现成单特异性细胞毒性 T 细胞
Scalable generation of hematopoietic stem cell-engineered off-the-shelf mono-specific cytotoxic T cells targeting solid tumors.
实体瘤的过继性 T 细胞治疗受到自体制造复杂性的限制,而在异体环境中还存在移植物抗宿主病(GvHD)、HLA 限制和供者变异性等风险。
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Scalable generation of hematopoietic stem cell-engineered off-the-shelf mono-specific cytotoxic T cells targeting solid tumors.
实体瘤的过继性 T 细胞治疗受到自体制造复杂性的限制,而在异体环境中还存在移植物抗宿主病(GvHD)、HLA 限制和供者变异性等风险。
Cooperative Armoring of CAR and TCR T Cells by T Cell-Restricted IL15 and IL21 Universally Enhances Solid Tumor Efficacy.
膜锚定 IL15 与 IL21 的共表达是一项增强工程化 T 细胞抗实体瘤韧性与功能的技术,可能适用于多种治疗平台和疾病。
Locoregional and systemic adoptive cellular therapies for pediatric brain tumors: a systematic review of CAR‑T, TCR‑engineered T cells, and NK cell st
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Unconventional T cells in anti-cancer immunity.
与识别负载于主要组织相容性复合体(MHC)分子上的肽类抗原的常规 T 细胞不同,非常规 T 细胞响应由 MHC I 类样蛋白(如 CD1 和 MHC 相关蛋白 1(MR1))呈递的非肽类代谢物抗原。
Engineered Cellular Therapies for the Treatment of Thoracic Cancers.
胸部恶性肿瘤(肺癌和恶性胸膜间皮瘤)在世界范围内普遍存在,且与高发病率和高死亡率相关。
Acute Myeloid Leukemia Skews Therapeutic WT1-specific CD8 TCR-T Cells Towards an NK-like Phenotype that Compromises Function and Persistence.
异基因造血细胞移植(HCT)后复发和/或难治的急性髓系白血病(AML)通常致命。
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