可扩展生成靶向实体瘤的造血干细胞工程化现成单特异性细胞毒性 T 细胞
Scalable generation of hematopoietic stem cell-engineered off-the-shelf mono-specific cytotoxic T cells targeting solid tumors.
实体瘤的过继性T细胞治疗受到自体制造复杂性的限制,而在异体环境中还存在移植物抗宿主病(GvHD)、HLA限制和供者变异性等风险。
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Scalable generation of hematopoietic stem cell-engineered off-the-shelf mono-specific cytotoxic T cells targeting solid tumors.
实体瘤的过继性T细胞治疗受到自体制造复杂性的限制,而在异体环境中还存在移植物抗宿主病(GvHD)、HLA限制和供者变异性等风险。
Advances and prospects in cell therapy for cancer: explorations from T cells to stem cells.
全球癌症负担日益加重,亟需创新的治疗策略。
Engineered TCR-T cells secreting IFNα/anti-PD-L1 potentiate endogenous immunity to synergistically bolster the efficacy against solid tumors.
T 细胞受体工程化 T 细胞(TCR-T)疗法是治疗实体瘤的一种有前景的方法。
Cell-Type-Tailored Hydrogels for Adoptive Cell Therapy in Cancer.
水凝胶赋能的过继细胞疗法(ACT)为改善实体瘤的细胞免疫治疗提供了一种局部且可控的策略。
Cell therapy in sarcoma: current landscape and future directions.
肉瘤是起源于间充质的罕见恶性肿瘤,具有显著的生物学与临床异质性。
Immune cell-based therapies for solid tumors, current challenges and therapeutic advances.
实体瘤仍难以治疗,原因在于抗原异质性、限制免疫细胞迁移的物理屏障以及深度免疫抑制的肿瘤微环境(TME)。
Engineering Strategies for Allogeneic T Cell-Based Platforms in Cancer Immunotherapy.
异体T细胞疗法已成为一种有前景的策略,可克服自体疗法的物流和生产限制,实现可扩展的现货型癌症免疫治疗。
Reprogramming adoptive cell therapy for osteosarcoma: engineering, vaccination, and tumor microenvironment remodeling.
骨肉瘤仍是治疗上的重大挑战,尤其是对于复发、难治或转移性疾病的患者。
Molecular understanding and clinical aspects of adoptive cellular immunotherapy in prostate cancer.
过继性细胞免疫治疗(ACT)是一种里程碑式的治疗策略,通过输注体外激活并扩增的自体淋巴细胞,直接清除肿瘤细胞或增强抗肿瘤免疫。
Recent advances and challenges of cellular immunotherapies in lung cancer treatment.
本文总结并强调了细胞免疫疗法用于治疗肺癌的最新进展和挑战,这可能为细胞免疫疗法的进一步发展激发新思路。
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