CELL INTELLIGENCE · 肿瘤细胞治疗研究

使用第二近红外共轭寡电解质探针的过继免疫细胞分布与扩增超灵敏体内成像

Ultrasensitive In Vivo Imaging of Adoptive Immune Cell Distribution and Expansion Using Second Near-Infrared Conjugated Oligoelectrolyte Probes.

内源性免疫组分在复发 GBM CAR-T 细胞治疗后的关键作用

The critical role of the endogenous immune compartment after CAR T cell therapy in recurrent GBM.

开发基于溶瘤病毒递送 CD19 和 EGFRvIII 抗原与双特异性 CAR 的胶质母细胞瘤多模式治疗

Developing a multimodal therapy for glioblastoma using oncolytic virus delivering CD19 and EGFRvIII antigens and bi-specific CARs.

分泌 IL-12 的 CAR-T 细胞重编程肿瘤微环境并提高对异质性胶质母细胞瘤模型的疗效

IL-12-secreting CAR-T cells reprogram the tumor microenvironment and improve efficacy against heterogeneous models of glioblastoma.

本研究证明了 IL-12 装甲 CAR-T 细胞的多效性益处，其改善了对抗原阳性肿瘤细胞的靶向，并同时重塑微环境以调动适应性免疫对抗抗原阴性克隆。该策略通过规避毒性淋巴细胞清除的需求并解决肿瘤异质性，提供了一种潜在临床可操作的方法来改善 GBM 的结局。

靶向胶质母细胞瘤中的肿瘤免疫生态系统：免疫治疗的挑战和创新

Targeting the Tumor Immune Ecosystem in Glioblastoma: Challenges and Innovations in Immunotherapy.

异体干细胞工程化 EGFRvIII 特异性 CAR-NKT 细胞治疗胶质母细胞瘤，疗效和安全性增强

Allogeneic stem cell-engineered EGFRvIII-specific CAR-NKT cells for treating glioblastoma with enhanced efficacy and safety.

从实验台到临床：实体恶性肿瘤 CAR-T 细胞治疗的新兴范式

From Bench to Bedside: Emerging Paradigms in CAR-T Cell Therapy for Solid Malignancies.

解析免疫微环境：髓母细胞瘤亚型的精准免疫治疗

Decoding the immune microenvironment: precision immunotherapy for medulloblastoma subtypes.

靶向 COX-2/PGE(2) 轴增强脑肿瘤中 NK 和 T 细胞免疫治疗

Targeting the COX-2/PGE(2) axis to enhance NK and T cell immunotherapy in brain tumors.

CAR-T 细胞、CAR NK 细胞和 CAR 巨噬细胞在胶质瘤模型中的不同特征及与细胞因子联合时的类似增强

CAR T cells, CAR NK cells, and CAR macrophages exhibit distinct traits in glioma models but are similarly enhanced when combined with cytokines.