CELL INTELLIGENCE · 肿瘤细胞治疗研究

恶性胸膜间皮瘤的免疫治疗耐药与策略

Immunotherapy resistance and strategies in malignant pleural mesothelioma.

通用型脐带血来源、靶向间皮素的 CAR-T 细胞的制备及抗肿瘤应用

Preparation and anti-tumor applications of universal umbilical cord blood-derived, mesothelin-targeted CAR-T cells.

抗 PD-1 纳米抗体装甲 MSLN CAR-T 治疗恶性间皮瘤：临床前与临床研究

Anti-PD-1 Nanobody-Armored MSLN CAR-T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies.

靶向间皮素的新型多链 DAP-CAR-T 细胞在卵巢癌和间皮瘤中的疗效与安全性：一项单臂、开放标签、首次人体研究

Efficacy and safety of novel multiple-chain DAP-CAR-T cells targeting mesothelin in ovarian cancer and mesothelioma: a single-arm, open-label and firs

我们的研究突出了靶向 MSLN 的多链 DAP-CAR-T 细胞疗法治疗卵巢癌和间皮瘤患者的安全性和疗效。

突破传统间皮素靶向 CAR-T 细胞治疗恶性间皮瘤的治疗荒漠：未来展望

Breaking through the treatment desert of conventional mesothelin-targeted CAR-T cell therapy for malignant mesothelioma: A glimpse into the future.

间皮素靶向 CAR-T 细胞的区域递送在小鼠中有效且安全地靶向结直肠癌肝转移

Regional delivery of mesothelin-targeted chimeric antigen receptor T-cell effectively and safely targets colorectal cancer liver metastases in mice.

MSLN 靶向 CAR-T 细胞疗法的区域递送在原位 CRLM NSG 小鼠模型和 PDX 模型中具有令人鼓舞的结果，并将肿瘤微环境从冷肿瘤转化为热肿瘤。本研究可能为 CRLM 提供一种新的治疗途径。需要进一步的临床研究。