CELL INTELLIGENCE · 肿瘤细胞治疗研究

年轻化造血干/祖细胞工程化 CAR 装甲自然杀伤 T 细胞用于恶性胸膜间皮瘤

Rejuvenated Hematopoietic Stem and Progenitor Cell-Engineered CAR-Armored Natural Killer T Cells for Malignant Pleural Mesothelioma.

用于生成靶向子宫内膜癌的同种异体 CAR 导向自然杀伤 T 细胞的干细胞工程

Stem cell engineering for the generation of allogeneic CAR-directed natural killer T cells targeting endometrial carcinoma.

这些发现凸显了 Allo MCAR-NKT 细胞作为安全有效的现货型细胞免疫疗法，用于治疗 UEC 以及可能其他具有免疫抑制微环境特征的实体瘤的潜力。

IL-15 增强间皮素和 CD70 CAR NK 细胞在 PDAC 中的效力，双靶向未带来额外获益

IL-15 boosts mesothelin- and CD70-CAR NK cell potency in PDAC without added benefit from dual targeting.

靶向间皮素的新型多链 DAP-CAR-T 细胞在卵巢癌和间皮瘤中的疗效与安全性：一项单臂、开放标签、首次人体研究

Efficacy and safety of novel multiple-chain DAP-CAR-T cells targeting mesothelin in ovarian cancer and mesothelioma: a single-arm, open-label and firs

我们的研究突出了靶向 MSLN 的多链 DAP-CAR-T 细胞疗法治疗卵巢癌和间皮瘤患者的安全性和疗效。

促纤维增生性间质限制 T 细胞外渗并介导实体瘤中的免疫排斥和免疫抑制

Desmoplastic stroma restricts T cell extravasation and mediates immune exclusion and immunosuppression in solid tumors.

异体干细胞工程化间皮素重定向 CAR-NKT 细胞靶向原位与转移性胰腺癌

Targeting orthotopic and metastatic pancreatic cancer with allogeneic stem cell-engineered mesothelin-redirected CAR-NKT cells.

CAR-T 细胞中利用 microRNA 介导基因沉默的多重工程改造

Multiplex engineering using microRNA-mediated gene silencing in CAR T cells.

通过靶向 miRNA 实现的可滴定多重基因沉默为 CAR-T 细胞提供了基因编辑之外的替代方案，在效力、持久性、转移预防和免疫逃逸方面对异体产品具有潜在优势。

间皮素在妇科肿瘤中的作用及其在靶向治疗中的意义——综述

The Role of Mesothelin in Gynecological Tumors and Its Significance in Targeted Therapies-A Review.

NKT 细胞和 γδ T 细胞在靶向间皮素的胰腺癌免疫治疗中的疗效

Efficacy of natural killer T and gammadelta T cells in mesothelin-targeted immunotherapy of pancreatic cancer.

脐带血来源 CAR-NK 细胞：肿瘤免疫治疗的新兴即用型平台

Umbilical cord blood-derived CAR-NK cells: an emerging off-the-shelf platform for cancer immunotherapy.