αvβ3 CAR-T 细胞同时靶向肿瘤和转移灶,在黑色素瘤和三阴性乳腺癌的临床前模型中产生高度有效的控制
αvβ3 CAR-T Cells Simultaneously Targeting Tumor and Metastases Produce Highly Effective Control in Preclinical Models of Melanoma and Triple-Negative
本文测试了两种版本的v 3 CAR-T构建体,分别含有CD28或4-1BB共刺激结构域。
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αvβ3 CAR-T Cells Simultaneously Targeting Tumor and Metastases Produce Highly Effective Control in Preclinical Models of Melanoma and Triple-Negative
本文测试了两种版本的v 3 CAR-T构建体,分别含有CD28或4-1BB共刺激结构域。
The promise of TIL therapy for glioblastoma.
TIL(肿瘤浸润淋巴细胞)疗法已在难治性黑色素瘤中显示出疗效,并在肺癌中产生持久缓解。
Targeting the tumor microenvironment in glioblastoma: Mechanistic insights, therapeutic strategies, and advances in immunotherapy.
胶质母细胞瘤(GBM)是一种IV级胶质瘤,是最恶性的星形细胞瘤,起源于星形胶质细胞。
Functional Repurposing of Magnetic Nanoparticle-Assisted Hyperthermia for Immune Cell Labelling and Tracking.
免疫细胞疗法在血液系统恶性肿瘤中显示出前景,并且在肺癌、黑色素瘤和结直肠癌等实体瘤中正变得越来越有效。
Polyclonal expansion of functional tumor-reactive lymphocytes infiltrating glioblastoma for personalized cell therapy.
Tr-TILs 在 161 例患者中的 87 例中成功扩增,扩增率为 54%。
Novel fusion superkine, IL-24S/IL-15, enhances immunotherapy of brain cancer.
使用FSK(由IL-24S与IL-15融合而成)进行治疗,可促进GBM细胞杀伤,并通过招募和激活免疫细胞重塑TME,这支持了开发安全有效的癌症免疫治疗融合蛋白以及在脑内选择性递送用于GBM治疗的可行性。
Co-targeting of epigenetic regulators and BCL-XL improves efficacy of immune checkpoint blockade therapy in multiple solid tumors.
我们报道了一种结合表观遗传和BCL-XL抑制剂与ICB的新型方案,该方案在多种实体瘤的临床前模型中产生了强效的抗肿瘤反应。
Bacterial RNA downregulates MHC-I in tumor cell lines, promoting NK response and delaying tumor growth.
我们建立的MHC-I下调模型(通过bacRNA或合成hTLR8激动剂)可作为促进抗肿瘤反应的治疗策略。
Human induced pluripotent stem cell-derived chimeric antigen receptor-macrophages eradicate IL-13Rα2-positive solid tumors.
这些结果证明了iPSC来源的、靶向IL-13Rα2的CAR巨噬细胞具有强效的抗肿瘤活性和良好的安全性,支持其针对实体瘤的治疗潜力。
Neoadjuvant triplet immune checkpoint blockade in newly diagnosed glioblastoma.
17个月后,仍无明确的复发迹象。
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