下一代基于抗体的癌症治疗:抗体-药物偶联物和双特异性抗体在血液系统恶性肿瘤和实体瘤中的应用
Next-generation antibody-based therapeutics in cancer: antibody-drug conjugates bispecific antibodies across hematologic malignancies and solid tumors
肿瘤学的治疗范式正在经历由抗体药物偶联物(ADC)和双特异性抗体(bsAb)驱动的深刻变革。
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Next-generation antibody-based therapeutics in cancer: antibody-drug conjugates bispecific antibodies across hematologic malignancies and solid tumors
肿瘤学的治疗范式正在经历由抗体药物偶联物(ADC)和双特异性抗体(bsAb)驱动的深刻变革。
Antibody Response in Immunocompromised Patients With Hematologic Cancers Who Received a 3-Dose mRNA-1273 Vaccination Schedule for COVID-19.
本队列研究的结果支持,对于患有血液系统恶性肿瘤的免疫功能低下患者,初次接种计划应补充延迟的第三剂疫苗接种。B细胞淋巴瘤患者和异基因HCT受者需要在治疗或移植后重新接种疫苗。
Trends in Nephrology: From nihilism to targeted treatment of antibody-mediated rejection.
抗CD38抗体目前构成了治疗AMR证据最强的药物类别。
Translating B-Cell and Plasma-Cell Targeting from Oncology to Autoimmunity: Modalities, Quantitative Bridging, and a Development Roadmap.
B 细胞通过自身抗体产生、抗原提呈和细胞因子失调,以及致病性 B 细胞或浆细胞区室的持续存在,驱动 B 细胞恶性肿瘤和多种自身免疫性疾病。
Delineating MYC-Mediated Escape Mechanisms from Conventional and T Cell-Redirecting Therapeutic Antibodies.
MYC 高表达的肿瘤细胞通过几种互不重叠的机制削弱了治疗性抗体的疗效。
A Dose Escalating Study of CD19/CD22/BCMA CAR-T Therapy in Relapsed/ Refractory Multiple Myeloma
这是一项早期 I 期注册临床试验,评估 CD19CAR-T 细胞治疗多发性骨髓瘤的安全性、可行性及初步疗效。当前状态:招募中。计划入组 12 例。试验地点:中国 · 上海(共 1 个中心,其中中国 1 个)。登记号:NCT06732232。
SOHO State of the Art Updates and Next Questions | Novel Immunotherapy Combinations for the Treatment of Indolent B-Cell Lymphoma.
化学免疫治疗(CIT)是晚期惰性非霍奇金淋巴瘤(iNHL)的标准一线治疗。
Enrichment of CD4(+) and CD8(+) T lymphocytes with a column-free flow-based device for clinical cell manufacturing.
我们的数据显示,CD4/CD8富集迅速且稳定,富集时间缩短至1小时或更短。
Efficacy of Multiple SARS-CoV-2 Vaccine Doses in Patients with B Cell Hematologic Malignancies Receiving Chimeric Antigen Receptor T Cell Therapy: A C
严重急性呼吸综合征冠状病毒2(SARS-CoV-2)在嵌合抗原受体(CAR)T细胞治疗(CAR-T)接受者中的死亡率接近40%。
The Novel Therapeutic Landscape for Relapsed/Refractory Diffuse Large B Cell Lymphoma.
弥漫大 B 细胞淋巴瘤(DLBCL)是一种侵袭性恶性肿瘤,传统上采用以蒽环类药物为基础的化疗,但约三分之一的患者在一线治疗后复发或存在原发难治。
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