CELL INTELLIGENCE · 肿瘤细胞治疗研究

GPC3 嵌合抗原受体 (CAR)-NK 细胞联合 Enoblituzumab 增强抗肝细胞癌疗效

GPC3 chimeric antigen receptor (CAR)-NK cells combined with Enoblituzumab enhance the anti-tumor efficacy against hepatocellular carcinoma.

肝细胞癌嵌合抗原受体（CAR）T 细胞治疗近期进展综述

A Review of Recent Advances in Chimeric Antigen Receptor (CAR) T-Cell Therapy for Hepatocellular Carcinoma.

EB-G3B7-NK dual-target CAR-NK（GPC3 NK 细胞）治疗肝细胞癌、肝癌：I/II 期临床试验

Dual-Target GPC3/B7-H3 CAR-NK Cells for Advanced HCC

这是一项 I/II 期注册临床试验，评估 NK 细胞治疗肝细胞癌、肝癌的疗效与安全性。当前状态：招募中。计划入组 30 例。试验地点：中国 · 深圳（共 1 个中心，其中中国 1 个）。登记号：NCT07500220。

不可逆电穿孔与 CAR-NK 细胞疗法对肝细胞癌的协同免疫治疗效果

Synergistic immunotherapeutic effects of irreversible electroporation and CAR-NK cell therapy against hepatocellular carcinoma.

IL-18 代谢重编程表达 CAR 的自然杀伤 T 细胞并增强其抗肿瘤活性

IL-18 metabolically reprograms CAR-expressing natural killer T cells and enhances their antitumor activity.

新型靶向磷脂酰肌醇蛋白聚糖 3（GPC3）的 CAR-T 细胞疗法 JWATM204 治疗晚期肝细胞癌的安全性和疗效：一项 I 期剂量递增研究

Safety and efficacy of JWATM204, a novel Glypican-3 (GPC3)-targeted CAR T cell therapy for advanced hepatocellular carcinoma: A phase I dose-escalatio

JWATM204 在晚期 GPC3 阳性 HCC 患者中表现出良好的安全性特征，并显示出初步的抗肿瘤活性。外周血 NK 细胞水平以及肿瘤 CRP 和 CYP2E1 表达可能作为治疗反应的潜在生物标志物，为进一步优化 HCC 的 CAR-T 细胞治疗提供了依据。

靶向磷脂酰肌醇蛋白聚糖 3 的肝细胞癌联合治疗策略：一篇综合性综述

Combination therapy strategies targeting glypican-3 in hepatocellular carcinoma: A comprehensive review.

Glypican-3 特异性 CAR NK 细胞共分泌 IL-15 和 IFN-α 在体外对肝细胞癌具有增强的抗肿瘤功能

Glypican-3-Specific CAR NK Cells Co-Secreting IL-15 and IFN-α Have Increased Anti-Tumor Function Versus Hepatocellular Carcinoma In Vitro.

GPC3 CAR-iNKT 细胞在肝细胞癌小鼠模型中的抗肿瘤作用

Anti-tumor effects of GPC3 CAR-iNKT cells in murine models of hepatocellular carcinoma.

经 mRNA-LNP 平台靶向递送 IFN-α-抗 GPC3 融合蛋白在肝细胞癌中激发强效抗肿瘤免疫

Targeted delivery of IFN-α-anti-GPC3 fusion protein via mRNA-LNP platform elicits potent anti-tumor immunity in hepatocellular carcinoma.