CELL INTELLIGENCE · 肿瘤细胞治疗研究

急性髓系白血病双特异性抗体：从骨髓免疫龛到临床转化

Bispecific Antibodies for Acute Myeloid Leukemia: From Bone Marrow Immune Niche to Clinical Translation.

寻找 AML 中安全有效的 CAR-T 靶点

The search for safe and effective CAR-T targets in AML.

TNF-α和 IFN-γ差异性调节 AML 细胞对 CD70 抗体介导的细胞毒性的敏感性

TNF-α and IFN-γ differentially regulate AML cell susceptibility to CD70-antibody-mediated cytotoxicity.

CD70 是 AML 中 NK 细胞免疫治疗的一个有前景的靶点。然而，AML 细胞上 HLA 分子的 IFN-γ依赖性上调导致对 ADCC 的耐药。这些发现强调了在临床试验中需要合理的联合策略来克服这种可诱导的免疫逃逸机制。

急性髓系白血病 CAR-T 细胞治疗的新兴策略：通过双抗原靶向克服异质性并提高安全性

Emerging strategies in CAR-T cell therapy for acute myeloid leukemia: overcoming heterogeneity and improving safety through dual-antigen targeting.

IL-21/IL-21R 信号使急性髓系白血病干细胞对阿糖胞苷治疗和 CAR-T 细胞治疗更敏感

IL-21/IL-21R signaling renders acute myeloid leukemia stem cells more susceptible to cytarabine treatment and CAR T cell therapy.

蛋白酶体抑制增强表达嵌合抗原受体（CAR）的 NK 细胞对急性髓系白血病的抗白血病疗效

Proteasome inhibition enhances the anti-leukemic efficacy of chimeric antigen receptor (CAR) expressing NK cells against acute myeloid leukemia.

PIs 在体外和体内增强表达 CAR 的同种异体 NK 细胞对急性髓系白血病的抗白血病疗效，值得在早期临床试验中进一步探索这种联合治疗。

敲除 CD70 使 CD70 特异性 NanoCAR T 细胞免于抗原诱导的耗竭

Knocking Out CD70 Rescues CD70-Specific NanoCAR T Cells from Antigen-Induced Exhaustion.

超越骨髓：髓外多发性骨髓瘤肿瘤综合下一代测序的见解

Beyond the marrow: insights from comprehensive next-generation sequencing of extramedullary multiple myeloma tumors.

靶向胶质母细胞瘤的嵌合抗原受体：现状与未来展望

Current and future perspectives of chimeric antigen receptors against glioblastoma.