CELL INTELLIGENCE · 肿瘤细胞治疗研究

靶向白血病干细胞的脂质体纳米免疫疗法通过沉默 B 细胞淋巴瘤 2 逆转免疫逃逸并抑制融合癌蛋白驱动的急性髓系白血病

Leukemic Stem Cell-Targeted Liposomal Nanoimmunotherapy Reverses Immune Evasion and Inhibits Fusion Oncoprotein-Driven Acute Myeloid Leukemia by Silen

高维光谱流式细胞术揭示 CLL 小鼠模型中进行性 T 细胞耗竭和髓系细胞重编程

High-dimensional spectral flow cytometry uncovers progressive T-cell exhaustion and myeloid cell reprogramming in a CLL mouse model.

一种新型三基因敲除同种异体 BCMA CAR-T 细胞疗法（CT0590）用于多发性骨髓瘤：临床前及 1 期研究

A novel triple-knockout allogeneic BCMA CAR T-cell therapy (CT0590) for multiple myeloma: preclinical and phase 1 study.

分泌抗 CD73 scFv 的增强型 CD33 CAR-NK 细胞克服腺苷介导的免疫抑制并提高抗 AML 疗效

Enhanced CD33 CAR-NK cells secreting anti-CD73scFv overcome adenosine-mediated immunosuppression and improve anti-AML efficacy.

CD33-CD73 双靶向 CAR-NK 平台协同靶向 AML 细胞和富含腺苷的肿瘤微环境，展现出更优的抗白血病疗效。

靶向 TIM3 递送 venetoclax 克服急性髓系白血病耐药并重振 NK 细胞活性

TIM3-targeted delivery of venetoclax overcomes drug resistance and reinvigorates NK cell activity in acute myeloid leukemia.

表面蛋白质组 CRISPR 激活筛选揭示调控肿瘤对 NK 细胞杀伤敏感性的配体

Surfaceome CRISPR activation screening uncovers ligands regulating tumor sensitivity to NK cell killing.

细胞因子诱导的可扩增记忆 NK 细胞具有显著的代谢、表观遗传重塑和持久性特性

Cytokine-induced expandable memory NK cells with significant metabolic, epigenetic remodeling, and persistence properties.

来那度胺通过 CD28、Notch 信号通路及 IL-2 释放增强 CD1d-Vδ2 双特异性抗体介导的 Vγ9Vδ2-T 细胞效应功能

Lenalidomide boosts CD1d-Vδ2 bispecific antibody-engaged Vγ9Vδ2-T cell effector functions via CD28, Notch signaling and IL-2 release.

我们的发现为在 CD1d 表达的血液系统恶性肿瘤患者中探索 CD1d-Vδ2 bsTCE 与 IMiD 来那度胺的联合治疗提供了依据。

基于转录组的慢性髓性白血病无治疗缓解多变量预测模型的开发与外部验证

Development and External Validation of a Transcriptome-Based Multivariable Prediction Model for Treatment-Free Remission in Chronic Myeloid Leukemia.

这些发现表明，在停用 TKI 时进行转录组分析可预测 CML 患者的 TFR 结局，并为持续 TFR 的潜在机制提供生物学见解。

探索 CAR-T 之外的 CAR 细胞疗法用于髓系恶性肿瘤

Exploring CAR cell therapies beyond CAR-T for myeloid malignancies.