下一代基于抗体的癌症治疗:抗体-药物偶联物和双特异性抗体在血液系统恶性肿瘤和实体瘤中的应用
Next-generation antibody-based therapeutics in cancer: antibody-drug conjugates bispecific antibodies across hematologic malignancies and solid tumors
肿瘤学的治疗范式正在经历由抗体药物偶联物(ADC)和双特异性抗体(bsAb)驱动的深刻变革。
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Next-generation antibody-based therapeutics in cancer: antibody-drug conjugates bispecific antibodies across hematologic malignancies and solid tumors
肿瘤学的治疗范式正在经历由抗体药物偶联物(ADC)和双特异性抗体(bsAb)驱动的深刻变革。
T cells engineered against Dickkopf-1-A2 complex can be used to treat HLA-A2(+) solid and hematologic cancers.
本研究表明 DKK1-A2 CAR-T 细胞或可用于治疗人类癌症。
Targeting PIM2 improves antitumor immunity through promoting effector function and persistence of CD8 T cells.
PIM 激酶家族在肿瘤发生中起关键作用,但其在原代 T 细胞中的作用研究不足。
Parallel processing of T cells and natural killer cells to enhance in vivoCAR T cell activity against blood and solid cancers.
本研究鼓励优化利用白细胞单采产物。通过将废弃的PBMC回收为NK细胞,可有效增强CAR T细胞疗法,改善肿瘤清除率和生存率。
Engineering a Programmed Death-Ligand 1-Targeting Monobody Via Directed Evolution for SynNotch-Gated Cell Therapy.
程序性死亡配体1(PD-L1)因其抑制T细胞活化的能力,成为癌症免疫治疗的一个有前景的靶点;
IGM-7354, an Immunocytokine with IL15 Fused to an Anti-PD-L1 IgM, Induces NK and CD8+ T cell-Mediated Cytotoxicity of PD-L1-Positive Tumor Cells.
本研究表明,开发一种安全有效的基于IgM的免疫细胞因子用于治疗癌症是可行的,利用IgM抗体的多价性以高亲和力和亲合力结合PD-L1,并刺激NK和CD8+ T细胞效应器。
Targeting cancer stem cells with CAR-based immunotherapy: biology, evidence, and future directions.
癌症干细胞(CSCs)在肿瘤发生、进展和复发中起关键作用,凸显了靶向治疗以实现持久缓解的必要性。
The inter-link of ageing, cancer and immunity: findings from real-world retrospective study.
本研究提供了外周血PD-1阳性细胞百分比的参考范围,证实了免疫细胞减少以及伴随癌症的一系列免疫变化,扩展了我们的真实世界证据,以更好地理解衰老、癌症和免疫之间的相互作用。
C-X-C Motif Chemokine Ligand 9 Correlates with Favorable Prognosis in Triple-Negative Breast Cancer by Promoting Immune Cell Infiltration.
在此,我们通过组织芯片(TMA)评估了 268 例三阴性乳腺癌(TNBC)患者队列中 CXCL9 和程序性死亡配体 1(PD-L1)的表达模式。
Alterations in immune cell phenotype and cytotoxic capacity in HER2+ breast cancer patients receiving HER2-targeted neo-adjuvant therapy.
PBMCs在新辅助治疗完成后表现出表型和功能的改变。在离体ADCC试验中,抗PD-1响应的PBMCs可能是治疗反应的生物标志物。
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