CELL INTELLIGENCE · 肿瘤细胞治疗研究

CD81 通过阻断 CD274/PD-L1 的选择性自噬降解驱动放射抵抗性胶质母细胞瘤的免疫逃逸

CD81 drives immune evasion in radioresistant glioblastoma by blocking selective autophagic degradation of CD274/PD-L1.

整合血浆来源的循环蛋白与多组学方法以识别食管腺癌的潜在治疗靶点

Integrating plasma-derived circulating proteins with multi-omics approaches to identify potential therapeutic targets for esophageal adenocarcinoma.

仿生血小板膜包裹的纳米胶束通过协同缓解缺氧和激活免疫以增强 TNBC 的免疫治疗

Biomimetic platelet membrane-camouflaged nanomicelles for synergistic hypoxia alleviation and immune activation to potentiate immunotherapy in TNBC.

肿瘤免疫微环境中的外泌体环状 RNA：从调控机制到治疗机遇与转化障碍（综述）

Exosomal circular RNAs in the tumor immune microenvironment: From regulatory mechanisms to therapeutic opportunities and translational hurdles (Review

肾细胞癌中的 Eomesodermin：驱动肿瘤进展的表观遗传与免疫串扰（综述）

Eomesodermin in renal cell carcinoma: Epigenetic and immune crosstalk driving tumor progression (Review).

整合单细胞和空间转录组分析鉴定 LMX1B 作为肾细胞癌中调控 GDF15-ATP4B 轴的抑癌因子

Integrative single-cell and spatial transcriptomic analyses identify LMX1B as a tumor suppressor orchestrating the GDF15-ATP4B axis in renal cell carc

我们的整合多组学和功能分析确立了 LMX1B-GDF15-ATP4B 轴是 RCC 中关键的肿瘤抑制级联。这些发现阐明了发育必需的转录因子如何调控肾脏恶性肿瘤中的 TME 组织和线粒体稳态，并将 LMX1B 确定为 RCC 有前景的预后生物标志物和治疗靶点。

基于 DNA 超分子水凝胶的保护性 NK 细胞储库用于增强三阴性乳腺癌治疗

Protective NK Cell Reservoir Based on DNA Supramolecular Hydrogel for Enhanced Triple-Negative Breast Cancer Therapy.

胸腺嘧啶功能化 bPEI 纳米复合物用于协同 STING 激活和 PD-L1 沉默以增强癌症免疫治疗

Thymine-functionalized bPEI nanocomplexes for synergistic STING activation and PD-L1 silencing to potentiate cancer immunotherapy.

NK 细胞在卵巢癌治疗中的作用：机制、逃逸与治疗创新

Natural killer cells in ovarian cancer therapy: mechanisms, evasion, and therapeutic innovations.

放射性诱导的颞叶损伤破坏神经-免疫串扰：局部晚期鼻咽癌免疫功能障碍的关键驱动因素

Radiation-induced temporal lobe injury disrupts neuro-immune crosstalk: A key driver of immune dysfunction in locally advanced nasopharyngeal carcinom