CELL INTELLIGENCE · 肿瘤细胞治疗研究

癌症中的非常规免疫治疗：机遇与挑战

Unconventional Immunotherapies in Cancer: Opportunities and Challenges.

推进实体瘤 CAR 细胞疗法：挑战、治疗策略和展望

Advancing CAR-based cell therapies for solid tumours: challenges, therapeutic strategies, and perspectives.

不寻常的搭档：基于 γδ-TCR 的 T 细胞治疗联合溶瘤病毒治疗弥漫性中线胶质瘤

Unusual Partners: γδ-TCR-Based T Cell Therapy in Combination with Oncolytic Virus Treatment for Diffuse Midline Gliomas.

用编码 MUC1 双特异性抗体衔接器和 IL-2 细胞因子的新型腺病毒克服卵巢癌腹水中效应 T 细胞耗竭

Overcoming effector T cell exhaustion in ovarian cancer ascites with a novel adenovirus encoding for a MUC1 bispecific antibody engager and IL-2 cytok

一种溶瘤系统在胰腺肿瘤细胞中选择性产生氧气，以缓解缺氧并改善免疫激活

An oncolytic system produces oxygen selectively in pancreatic tumor cells to alleviate hypoxia and improve immune activation.

响应性氧气自供给 adv-MCK 级联反应系统联合光动力疗法可改善胰腺癌缺氧微环境并增强抗肿瘤免疫，为胰腺癌提供了一种有前景的替代治疗策略。

细菌外膜囊泡促进 Vγ9Vδ2 T 细胞的溶瘤活性

Bacterial outer-membrane vesicles promote Vγ9Vδ2 T cell oncolytic activity.

我们的发现首次表明，OMV 刺激可促进 Vγ9Vδ2 T 细胞的扩增，这些细胞随后表现出抗肿瘤能力。我们提出，OMV 介导的免疫激活利用了 Vγ9Vδ2 T 细胞的抗微生物/抗肿瘤能力，这一轴系可用于改进未来的治疗。

通过 mRNA 转染嵌合抗原受体或双特异性 T 细胞衔接器增强 γδ T 细胞有效性

Enhancing the effectiveness of γδ T cells by mRNA transfection of chimeric antigen receptors or bispecific T cell engagers.

癌症作为一种功能失调的免疫紊乱：基于宿主免疫通路完整更新框架的促肿瘤 TH1 样免疫反应和抗肿瘤 THαβ免疫反应

Cancer as a Dysfunctional Immune Disorder: Pro-Tumor TH1-like Immune Response and Anti-Tumor THαβ Immune Response Based on the Complete Updated Framew