肿瘤细胞治疗研究
FRONTIER PAPERS
Development and validation of an interpretable prediction model using spatial patterns of tumor-infiltrating lymphocytes in H&E-stained whole-slide im
本研究基于 H&E 染色切片中 TIL 的空间分布，建立了 LUAD 的可解释免疫亚型预测模型。
Smoking-Associated Enrichment of CXCL13(+) Tfh Cells and VCAM1(+) Fibroblasts Is Linked to Tertiary Lymphoid Structure Formation in Lung Adenocarcinom
吸烟相关的CXCL13 CD4 Tfh细胞富集与LUAD中B细胞积聚及TLS形成相关。这些发现将CXCL13 Tfh-B细胞轴以及VCAM1成纤维细胞丰富的基质微环境确定为LUAD中潜在的生物标志物和治疗靶点。
Organ-specific heterogeneity in tumor-infiltrating immune cells and cancer antigen expression in primary and autologous metastatic lung adenocarcinoma
在肺腺癌患者中，脑转移而非其他部位的转移，表现出相对免疫抑制的TIME；在脑转移对免疫治疗差异反应的背景下，这一点应予以考虑。在原发肿瘤中表达癌症抗原的患者中，大多数在转移灶中也有抗原表达；这些数据可为选择抗原靶向CAR以治疗转移性肺腺癌患者提供依据。
The dual immunomodulatory role of B cells in tumorigenesis: mechanisms, microenvironment crosstalk, and therapeutic implications.
B淋巴细胞在肿瘤生物学中展现出多面且依赖环境的作用，通过肿瘤微环境（TME）内的动态相互作用，既作为恶性肿瘤的促进者，也作为抑制者。
ITGAL expression in non-small-cell lung cancer tissue and its association with immune infiltrates.
ITGAL可作为评估NSCLC患者免疫微环境的生物标志物。
Intratumoral Abundance of M2-Macrophages is Associated With Unfavorable Prognosis and Markers of T-Cell Exhaustion in Small Cell Lung Cancer Patients.
小细胞肺癌（SCLC）约占肺癌病例的10%至15%。
Tumor microenvironment features decipher the outperformance of neoadjuvant immunochemotherapy over chemotherapy in resectable non-small cell lung canc
IO+化疗诱导的主要病理缓解（MPR）显著更高（75.0% vs.
Image analysis reveals molecularly distinct patterns of TILs in NSCLC associated with treatment outcome.
我们的结果提示，需要建立组织学亚型特异性的基于 TIL 的模型，用于生存风险分层和预测治疗应答。
Tumor-associated CD163(+) macrophage as a predictor of tumor spread through air spaces and with CD25(+) lymphocyte as a prognostic factor in resected
我们证明，M2 巨噬细胞密度较高是 STAS 发生率较高的独立预测因素。
Infiltration of NK and plasma cells is associated with a distinct immune subset in non-small cell lung cancer.
基于RNA测序数据，在197例患者中建立了转录组免疫模式。
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