肿瘤细胞治疗研究
英文原题：Mitochondria transfer: intercellular communication and tumor microenvironment dynamics.
线粒体作为古老的真核细胞器，是肿瘤微环境（TME）中细胞间通讯和物质交换的主要媒介，在调控肿瘤生长、转移和免疫逃逸中发挥关键作用。
线粒体作为古老的真核细胞器，是肿瘤微环境（TME）中细胞间通讯和物质交换的主要媒介，在调控肿瘤生长、转移和免疫逃逸中发挥关键作用。研究人员尤其关注线粒体转移途径及其对TME的后续影响。本综述不仅系统阐述了传统的线粒体转移途径，如隧道纳米管（TNTs）和细胞外囊泡（EVs），还进一步强调了新兴机制，特别是由迁移体和收缩体介导的线粒体转移。文章系统探讨了线粒体转移对肿瘤免疫和免疫治疗耐药性的功能影响。值得注意的是，我们讨论了基于CAR-T的线粒体调控策略作为潜在治疗干预措施的最新进展。通过整合这些新视角，本综述旨在为肿瘤生物学中线粒体转移提供更新的机制和转化研究见解。
Mitochondria, an ancient eukaryotic organelle, serve as a primary medium for intercellular communication and material exchange in tumor microenvironments (TME), playing a pivotal role in regulating tumor growth, metastasis, and immune evasion. Researchers have focused particularly on mitochondrial transfer pathways and their subsequent impacts on the TME. This review not only systematically elucidates traditional mitochondrial transfer pathways, such as tunneling nanotubes (TNTs) and extracellular vesicles (EVs), but also further emphasizes emerging mechanisms, particularly mitochondrial transfer mediated by migrasomes and retractosomes. It systematically explores the functional impacts of mitochondrial transfer on tumor immunity and immune therapy resistance. Notably, we discuss the latest advancements in mitochondrial modulation strategies based on CAR-T as potential therapeutic interventions. By integrating these novel perspectives, this review aims to provide updated mechanistic and translational research insights into mitochondrial transfer in cancer biology.
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