决定异体 CAR T 细胞排斥与扩增的细胞和分子机制
Cellular and molecular mechanisms determining allogeneic CAR T cell rejection and expansion.
我们评估了11例接受单一批次cemacabtagene ansegedleucel(cema-cel)治疗的大B细胞淋巴瘤患者,cemacabtagene ansegedleucel是一种异体抗CD19 CAR T产品。
英文原题:Two Drugs, One Stunning Myeloma Result.
通过将靶向BCMA的T细胞衔接器与抗CD38抗体配对使用,研究人员在复发骨髓瘤患者中实现了显著深度的缓解,并大幅降低了复发风险。
通过将靶向BCMA的T细胞衔接器与抗CD38抗体配对使用,研究者在复发骨髓瘤患者中实现了显著深度的缓解,并大幅降低了复发风险。结果提示,这种双重免疫导向策略可能挑战当前的治疗排序,包括何时部署工程化T细胞疗法。
By pairing a BCMA-targeted T-cell engager with an anti-CD38 antibody, researchers achieved strikingly deep remissions and sharply reduced relapse risk in patients with relapsed myeloma. The results suggest this dual immune-directed strategy could challenge current treatment sequencing, including when to deploy engineered T-cell therapies.
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