← 返回前沿论文

没有 BCMA?没问题:靶向 CD70 的 CAR-NK 细胞在高危骨髓瘤中展现前景

英文原题:No BCMA? No Problem: A CD70-Targeting CAR-NK Cell Shows Promise in High-risk Myeloma.

PubMed 2026/03/04(内容时间) Blood Cancer Discov Q1 · IF 12.2(JCR 2025)

研究概要

尽管近期取得了进展,多发性骨髓瘤对大多数患者仍基本上无法治愈,尤其是具有高危细胞遗传学特征的患者以及在接受 BCMA 靶向治疗后疾病复发的患者。

中文摘要

尽管近期取得了进展,多发性骨髓瘤对大多数患者而言本质上仍无法治愈,尤其是那些具有高危细胞遗传学特征以及在接受 BCMA 靶向治疗后疾病复发的患者。一种靶向 CD70 的新型 CD27 CAR_sIL15 NK 细胞可能为这一亟待满足的医疗需求领域带来新希望。参见 Lin 等人的相关文章,第 234 页。

展开英文摘要原文

Despite recent advances, multiple myeloma remains essentially incurable for most patients, particularly those with high-risk cytogenetics and those whose disease relapses after BCMA-targeting therapies. A novel CD27 CAR_sIL15 NK cell targeting CD70 may offer new hope in this area of urgent, unmet medical need. See related article by Lin et al., p. 234.

论文信息

作者
Benson DM Jr、Caligiuri MA
第一作者单位
Division of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio.United States
通讯作者单位
Division of Leukemia, Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, California.United States
期刊
Blood cancer discovery2026 Mar 4
原文标识
PubMed 41416759 · DOI 10.1158/2643-3230.BCD-25-0394