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CELL INTELLIGENCE · 肿瘤细胞治疗研究

CELL INTELLIGENCE 肿瘤细胞治疗研究

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γδ T 细胞与头颈部鳞状细胞癌

英文原题：γδ T cells and head and neck squamous cell carcinoma.

查看英文原题

γδ T cells and head and neck squamous cell carcinoma.

PubMed 2025/03/20（内容时间） Int Rev Cell Mol Biol
技术：γδ T 细胞头颈部鳞癌地区：中国
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研究概要

头颈部鳞状细胞癌（HNSCC）是一种常见且侵袭性强的恶性肿瘤，临床预后较差。

中文摘要

头颈部鳞状细胞癌（HNSCC）是一种常见且侵袭性强的恶性肿瘤，临床预后较差。免疫系统在肿瘤监视和治疗反应中起着关键作用。在各种免疫细胞群体中，γδ T（γδ T）细胞作为一种独特的淋巴细胞亚群，已成为抗肿瘤免疫应答的重要参与者，并在近期研究中受到广泛关注。本章讨论了γδ T细胞的独特特性、其在HNSCC中的作用，并评估了其作为HNSCC治疗靶点的潜在价值。

展开英文摘要原文

Head and neck squamous cell carcinoma (HNSCC) is a prevalent and aggressive malignant tumor with poor clinical prognosis. The immune system plays a critical role in tumor surveillance and response to therapy. Among various immune cell populations, γδ T (γδ T) cells, a unique subset of lymphocytes, have emerged as significant participants in the anti-tumor immune response and have attracted extensive attention in recent studies. This chapter discusses the unique properties of γδ T cells, their role in HNSCC, and evaluates their potential value as therapeutic targets for HNSCC.

论文信息

作者
Peng J、Qiu H、Bu LL、Wu Q
第一作者单位
School of Medicine, Wuhan University, Wuhan, P.R. China; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, School & Hospital of Stomatology, Wuhan University, Wuhan, P.R. China; Hubei Key Laboratory of Tumor Biological Behavior, Department of Radiation and Medical Oncology, Hubei Provincial Clinical Research Center for Cancer, Zhongnan Hospital of Wuhan University, Wuhan, P.R. China.China
通讯作者单位
Hubei Key Laboratory of Tumor Biological Behavior, Department of Radiation and Medical Oncology, Hubei Provincial Clinical Research Center for Cancer, Zhongnan Hospital of Wuhan University, Wuhan, P.R. China. Electronic address: wuqiuji@126.com.China
文献类型
综述 · 非美国政府资助研究
期刊
International review of cell and molecular biology2025
原文标识
PubMed 41110901　·　DOI 10.1016/bs.ircmb.2025.03.005

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