研究概要
本综述全面总结了胃癌(GC),包括其分类、病因、诊断以及免疫治疗在其治疗中的新兴应用。
中文摘要
这篇综述全面概述了胃癌(GC),包括其分类、病因、诊断以及免疫治疗在治疗中新兴的应用。文章探讨了Correa级联反应,即从正常黏膜发展为腺癌的过程,并讨论了GC的全球发病率和死亡率。文章讨论了Lauren分型、WHO分类和肿瘤分期,强调早期发现对于最佳治疗的必要性。文章探讨了GC的不同病因,包括幽门螺杆菌、EB病毒、遗传和环境因素,并描述了用于早期发现的诊断程序。最后,本综述旨在深入分析和概述GC和免疫治疗中最重要的主题,包括疾病发展、分类、危险因素、早期检测方法、治疗选择以及免疫治疗日益增长的重要性,还有生物标志物的重要性、正在进行的临床试验以及免疫治疗治疗GC的潜力。
展开英文摘要原文
This review provides a thorough summary of gastric cancer (GC), including its categorization, etiology, diagnosis, and the emerging use of immunotherapy in its treatment. It investigates the Correa Cascade, a development from normal mucosa to adenocarcinoma, and discusses the global incidence and mortality rates of GC. The article discusses the Lauren Classification, WHO classification, and tumor staging, emphasizing the necessity of early detection for optimal care. It investigates the different causes of GC, including Helicobacter pylori , Epstein-Barr Virus, hereditary and environmental variables, and describes the diagnostic procedures utilized for early detection. Finally, this review aims to provide an in-depth breakdown and overview of the most important topics in GC and immunotherapy, including disease development, classification, risk factors, early detection methods, treatment options, and the growing significance of immunotherapy, as well as the importance of biomarkers, ongoing clinical trials, and immunotherapy's potential to treat GC.
论文信息
- 作者
- Upasana、Kanugo A、Bhattacharya S
- 单位
- School of Pharmacy & Technology Management, SVKM'S NMIMS Deemed-to-be University, Shirpur, Maharashtra 425405, India.India
- 文献类型
- 综述
- 期刊
- ACS pharmacology & translational science2025 Jun 13