肿瘤细胞治疗研究
英文原题：Prospects for γδ T cells and chimeric antigen receptor γδ T cells in cancer immunotherapy.
Prospects for γδ T cells and chimeric antigen receptor γδ T cells in cancer immunotherapy.
γδ T 细胞是一类特殊的 T 细胞，因表面存在 γδ 链 T 细胞受体而有别于 αβ T 细胞。
γδ T细胞是一类特殊T细胞，与αβ T细胞不同，其表面表达γ链和δ链T细胞受体。这些受体使其能够直接识别并结合抗原分子，无需抗原与MHC结合或经抗原呈递细胞（APC）呈递。鉴于γδ T细胞的内在特性和功能多样性，研究者正深入探索其作为嵌合抗原受体（CAR）载体用于癌症治疗的潜力。在这一领域，CAR-T细胞通过双重抗原识别机制，有望克服抗原识别方面的局限。然而，仍有若干技术挑战亟待解决。本文讨论γδ T细胞及CAR-T细胞的研究现状和未来发展前景，旨在为CAR-T细胞后续研究及实际应用提供有价值的见解。
T cells, a type of specialized T cell, differ from alpha-beta T cells due to the presence of and chain surface T cell receptors. These receptors allow them to directly recognize and bind antigenic molecules without the requirement of attachment to MHC or APC antigen presentation. Given their intrinsic properties and functional versatility, T cells are under intensive investigation as carriers for chimeric antigen receptor (CAR) in the context of cancer therapy. In this regard, CAR-T cells have demonstrated great potential to overcome the limitations of antigen recognition with the help of dual antigen identification mechanisms. However, there are still technological challenges that need to be addressed. This discussion focuses on the research status and future development prospects of T cells and CAR-T cells, aiming to provide valuable insights for the follow-up research and practical application of CAR-T cells.
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