肿瘤细胞治疗研究
英文原题：The Role of STEAP1 in Prostate Cancer: Implications for Diagnosis and Therapeutic Strategies.
The Role of STEAP1 in Prostate Cancer: Implications for Diagnosis and Therapeutic Strategies.
前列腺癌（PCa）是最常见的恶性肿瘤之一，也是全球男性癌症相关死亡的第二大原因。
前列腺癌（PCa）是最常见恶性肿瘤之一，也是全球男性癌症相关死亡的第二大原因。前列腺六跨膜上皮抗原1（STEAP1）在PCa中异常高表达，即使在去势抵抗性前列腺癌（CRPC）阶段仍维持高水平，因此是有前景的诊断和治疗靶点。STEAP1阳性细胞外囊泡和STEAP1-PET成像是无创检测不同阶段PCa的有希望方法。STEAP1靶向疗法包括抗体偶联药物（ADC）、CAR-T 细胞、T细胞衔接器（TCE）和疫苗等，均显示治疗前景。本综述介绍STEAP1的结构及病理生理功能，总结STEAP1靶向分子成像和临床应用的前沿进展，并批判性分析其转化潜力，以克服当前PCa诊断和治疗的局限。
Prostate cancer (PCa) is one of the most common malignancies and the second leading cause of cancer-related death in men worldwide. The six-transmembrane epithelial antigen of the prostate 1 (STEAP1) is exceptionally overexpressed in PCa, maintaining high expression even in the castration-resistant prostate cancer (CRPC) stage, making it a promising target for diagnosis and treatment. STEAP1-positive extracellular vesicles and STEAP1-PET imaging are optimistic approaches for the non-invasive detection of different stages of PCa. STEAP1-targeted therapy includes an antibody-drug conjugate (ADC), chimeric antigen receptor T cell (CAR-T), T-cell engager (TCE), and vaccines, which demonstrate valuable therapeutic prospects. This review presents the structure and pathophysiological function of STEAP1, synthesizes cutting-edge advances in STEAP1-targeted molecular imaging and clinical applications, and critically analyzes their translational potential to overcome the limitations of current PCa diagnosis and treatment.
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