肿瘤细胞治疗研究
英文原题：Mesothelin as a Signal Pathways and Epigenetic Target in Cancer Therapy.
间皮素（MSLN）是一种糖蛋白类肿瘤抗原，在多种恶性肿瘤中升高并与不良预后相关，因为它可增强肿瘤的侵袭性、播散和化疗耐药。
间皮素（MSLN）是一种糖蛋白类肿瘤抗原，在多种恶性肿瘤中升高表达，并与不良预后相关，因为其可增强肿瘤侵袭、播散和化疗耐药。MSLN在表观遗传及信号通路调控中发挥关键作用，也可能成为重要生物标志物。MSLN靶向策略尤其与CA125/MUC16相关，有望改善肺癌、胰腺癌、结肠癌和卵巢癌的检测及治疗。靶向间皮素的CAR-NK细胞、²²⁷Th偶联物和CAR-T细胞等疗法已显示良好结果。间皮素靶向BiTE及联合CAR-T等新技术有望带来显著进展。针对间皮素的免疫疗法有潜力彻底改变治疗选择有限患者的癌症治疗方式。要全面理解MSLN机制并改善患者结局，仍需深入研究。本综述重点阐述MSLN在癌症进展中的复杂调控、细胞功能及临床意义。
Mesothelin (MSLN), a glycoprotein-based tumor antigen, is elevated in several malignancies and it is related to a poor prognosis, as it enhances tumor aggression, dissemination and chemotherapy resistance. MSLN plays a crucial role in epigenetic and signal pathway regulation and it can be an important biomarker. MSLN targeting is in particular, associated with CA125/MUC16, which offers the potential to improve lung, pancreatic, colon and ovarian cancer detection as well as therapeutic strategies. MSLNtargeted therapies have shown favorable results, such as CAR NK cells, 227Th conjugate and CAR-T cells, which target mesothelin. Significant advancements can be achieved with novel techniques, such as mesothelin-targeting BiTEs and simultaneous CAR-T cells. Immunotherapies targeting mesothelin have the potential to completely transform the way cancer is therapy in patients with limited options. To fully comprehend the mechanisms of MSLN, more investigation is required to explore its role in cancer for improved patient outcomes. The complex control, cellular functions and clinical significance of MSLN in the advancement of cancer are highlighted in this review.
MEMBER ACCOUNT
登录成功会直接打开下一页。
