肿瘤细胞治疗研究
英文原题：First reported case of a spontaneous and healthy pregnancy in a woman with persistent CAR T-cells 5 years after treatment for diffuse large B-cell lymphoma.
在此，我们报告一例复发难治性弥漫大B细胞淋巴瘤女性患者，接受实验性CAR T细胞治疗后获得缓解，CAR T细胞持续存在5年，随后自然妊娠并分娩一健康男婴。
CAR-T 细胞疗法显著推动癌症治疗进展并提高缓解率，但其对生育能力的影响，以及接受 CAR-T 治疗母亲所生婴儿的免疫状况仍有疑问。尚无已知报告显示妊娠期癌症治疗后 CAR-T 细胞持续存在。本文报告一例复发/难治性弥漫大 B 细胞淋巴瘤女性患者接受实验性 CAR-T 治疗后达到缓解，5 年后体内仍检测到 CAR-T 细胞，随后自然妊娠并诞下一名健康男婴。该病例表明，即便 CAR-T 细胞仍持续存在，也可能实现健康妊娠；新生儿健康，未见 CAR-T 细胞导致免疫或其他健康影响的证据。
Chimeric antigen receptor T-cell (CAR T-cell) therapy has significantly advanced cancer treatments and remission rates; however, questions exist regarding the impacts on both fertility and immune effects on infants born to mothers who have undergone CAR T-cell therapy. There are no known reported cases of persistence of CAR T-cells after cancer therapy in pregnancy. Here, we present a case of a woman with relapsed refractory diffuse large B-cell lymphoma who undertook an experimental CAR T-cell therapy, had persistence of CAR T-cells 5 years after achieving remission, spontaneously became pregnant and delivered a healthy male infant. Our case provides an example of a healthy pregnancy despite the persistence of CAR T-cells and the resultant healthy newborn without evidence of immunologic or other health effects from the CAR T-cells.
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