肿瘤细胞治疗研究
英文原题：Advances in the role of NK cells in MDS immune dysfunction and antitumor research.
骨髓增生异常综合征（MDS）是一组起源于造血干细胞的异质性髓系肿瘤，转化为急性髓系白血病（AML）的风险高。
骨髓增生异常综合征（MDS）是一组起源于造血干细胞的异质性髓系肿瘤，具有较高的急性髓系白血病（AML）转化风险。自然杀伤（NK）细胞在免疫监视和高效裂解肿瘤细胞方面至关重要，但在 MDS 中会因复杂的微环境和细胞因子动态变化而出现功能障碍。本文聚焦 MDS 中 NK 细胞功能障碍的机制，以及增强 NK 细胞活性、恢复其抗 MDS 效力的最新策略，并强调 NK 细胞在 MDS 治疗中的关键作用及潜力。
MDS is a heterogeneous group of myeloid neoplasms originating from hematopoietic stem cells, with a high risk of transformation into acute myeloid leukemia (AML). Natural Killer (NK) cells, crucial for their role in immune surveillance and efficient tumor cell lysis, experience functional impairments due to the complex microenvironment and cytokine dynamics in MDS. This article focuses on the mechanisms of NK cell dysfunction in MDS and the latest strategies to enhance NK cell activity to restore their anti-MDS efficacy, highlighting their key role and potential in MDS therapy.
MEMBER ACCOUNT
登录成功会直接打开下一页。
