肿瘤细胞治疗研究
英文原题：Expanding the Horizons of CAR-T Cell Therapy: A Review of Therapeutic Targets Across Diverse Diseases.
Expanding the Horizons of CAR-T Cell Therapy: A Review of Therapeutic Targets Across Diverse Diseases.
CAR-T细胞疗法在治疗恶性血液病方面已显示出令人鼓舞的结果。
CAR-T细胞疗法在治疗恶性血液病方面已显示出有前景的结果。该疗法的原理基于使用基因修饰的T淋巴细胞，使其膜上表达嵌合抗原受体（CAR），从而特异性识别主要表达于靶细胞上的抗原。CAR的分子设计，连同分子技术的进步以及“组学”的发展，为发现新的治疗靶点开辟了可能性，从而将CAR-T细胞治疗的疾病范围扩展到血液肿瘤中抗CD19和抗BCMA的使用之外。本综述总结了目前正在临床试验中用于CAR-T细胞治疗自身免疫性疾病和其他具有挑战性的病症（如心脏纤维化）以及不同感染的新型治疗靶点。此外，还讨论了扩大这种创新疗法临床可及性的挑战和新机遇。
CAR-T cell therapy has shown promising results in treating malignant hematologic diseases. The principle of this therapy is based on the use of genetically modified T lymphocytes to express a Chimeric Antigen Receptor (CAR) on their membrane that specifically recognizes an antigen predominantly expressed on target cells. The molecular design of the CAR, along with advancements in molecular techniques and the development of "omics", has opened the possibility of discovering new therapeutic targets and thereby expanding the range of diseases treated with CAR-T cells beyond the use of anti-CD19 and anti-BCMA for hematologic cancer. This review summarizes the novel therapeutic targets that are currently used in clinical trials with CAR-T cell therapy on autoimmune diseases and other challenging conditions, such as cardiac fibrosis, and different infections. Additionally, challenges and novel opportunities are discussed for expanding clinical access to this innovative therapy.
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